Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01166)
Name
Interferon alfa-2b
Synonyms    Click to Show/Hide the Synonyms of This API
INTERFERON ALFA-2B; Interferon alfa-2b, recombinant; 98530-12-2; C16H17Cl3I2N3NaO5S; SCHEMBL6041041; K779; Q4391540
Clinical Status
Approved
PubChem CID
71306834
Formula
C16H17Cl3I2N3NaO5S
Canonical SMILES
CCCN(CCOC1=C(C=C(C=C1Cl)Cl)Cl)C(=O)N2C=CN=C2.C(S(=O)(=O)[O-])(I)I.[Na+]
InChI
1S/C15H16Cl3N3O2.CH2I2O3S.Na/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18;2-1(3)7(4,5)6;/h3,5,8-10H,2,4,6-7H2,1H3;1H,(H,4,5,6);/q;;+1/p-1
InChIKey
MIXCUJKCXRNYFM-UHFFFAOYSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=71306834"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 746.5 Topological Polar Surface Area 113
XlogP N.A. Complexity 511
Heavy Atom Count 31 Rotatable Bond Count 7
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Interferon Alfa-2B 10miu/vial powder For Injection Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Sodium Phosphate Dibasic; Sodium Phosphate Monobasic; Edetate Disodium; Polysorbate80; M-Cresol
                   Dosage Form Powder For Injection
                   Company Schering
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Metacresol DIG Info Carcinoma MDA-MB-231 cells (IC50 = 27000 nM) [1]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
          Interferon Alfa-2B 50ug/0.5ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Dibasic Sodium Phosphate Anhydrous; Monobasic Sodium Phosphate Dihydrate; Sucrose; Polysorbate 80; Sterile Water
                   Dosage Form Solution
                   Company Schering
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
References
1 Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales). J Nat Prod. 2018 Dec 28; 81(12):2716-2721.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.