Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01200)
Name
Latanoprostene bunod
Synonyms    Click to Show/Hide the Synonyms of This API
Latanoprostene BUNOD; PF-3187207; BOL-303259-X; Vyzulta; NCX-116; 860005-21-6; NCX 116; UNII-I6393O0922; 4-nitrooxybutyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate; I6393O0922; Vesneo; Latanoprostene BUNOD [USAN:INN]; Vyzulta (TN); GTPL9635; CHEMBL2364612; SCHEMBL12119560; Latanoprostene bunod (USAN/INN); BCP29385; DB11660; 4-(Nitrooxy)butyl (5Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate; HY-19518; CS-0015617; D10441; Q27280492
Clinical Status
Approved
PubChem CID
11156438
Formula
C27H41NO8
Canonical SMILES
C1[C@H]([C@@H]([C@H]([C@H]1O)C/C=C\\CCCC(=O)OCCCCO[N+](=O)[O-])CC[C@H](CCC2=CC=CC=C2)O)O
InChI
1S/C27H41NO8/c29-22(15-14-21-10-4-3-5-11-21)16-17-24-23(25(30)20-26(24)31)12-6-1-2-7-13-27(32)35-18-8-9-19-36-28(33)34/h1,3-6,10-11,22-26,29-31H,2,7-9,12-20H2/b6-1-/t22-,23+,24+,25-,26+/m0/s1
InChIKey
LOVMMUBRQUFEAH-UIEAZXIASA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11156438"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 507.6 Topological Polar Surface Area 142
XlogP 4.4 Complexity 646
Heavy Atom Count 36 Rotatable Bond Count 18
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 8
Full List of Drug Formulations (DFMs) Containing This API
          Latanoprostene Bunod 0.24 mg/ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Polysorbate 80; Glycerin; Edta; Water
                   Dosage Form Solution
                   Company Bausch & Lomb orporated
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Edetic acid DIG Info Amyloid-beta A4 protein (IC50 = 7700 nM) [1]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
References
1 Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease. J Med Chem. 2013 Sep 12; 56(17):6775-91.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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