General Information of API (ID: D01234)
Name
Malathion
Synonyms    Click to Show/Hide the Synonyms of This API
malathion; Carbophos; 121-75-5; Carbofos; Mercaptothion; Karbofos; Phosphothion; Carbetox; Ethiolacar; Maldison; Prioderm; Sadophos; Cythion; Oleophosphothion; Chemathion; Sadofos; Ovide; Carbetovur; Fosfothion; Fosfotion; Malagran; Malakill; Malaphos; Malaspray; Malathon; Moscarda; Cimexan; Fyfanon; Malafor; Malamar; Malatol; Malatox; Malphos; Sumitox; Taskil; Etiol; Emmatos extra; Ortho Malathion; Siptox I; Extermathion; Forthion; Hilthion; Malacide; Malation; Mercaptotion; Kypfos; Malasol; Malathion E50; Malmed; Carbethoxy malathion; Malamar 50; Kop-thion; Compound 4049; Insecticide no. 4049; Detmol MA; Malathione; Emmatos; Malataf; Malathyl; Fosfotion 550; Malathion LV Concentrate; Zithiol; Staeubol-Puder; American cyanamid 4,049; Mercaptosuccinic acid diethyl ester; Latka 4049; SF 60; Experimental insecticide 4049; diethyl 2-dimethoxyphosphinothioylsulfanylbutanedioate; TM-4049; NCI-C00215; AC 26691; EL 4049; Four thousand forty-nine; C10H19O6PS2; O,O-Dimethyldithiophosphate diethylmercaptosuccinate; Diethyl (dimethoxyphosphinothioylthio)succinate; ENT 17,034; Dicarboethoxyethyl O,O-dimethyl phosphorodithioate; O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate; 8059HC; MLT; S-(1,2-Dicarbethoxyethyl) O,O-dimethyldithiophosphate; Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethyl phosphorodithioate; O,O-Dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate; S-1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyl thiophosphate; Calmathion; Cleensheen; Malathiazol; Camathion; Celthion; Dorthion; O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate; Flair; Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester; S-(1,2-Di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate; O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat; Butanedioic acid, ((dimethoxyphosphinothioyl)thio)-, diethyl ester; Butanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester; NSC-6524; diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate; Kill-A-Mite; Malation [Polish]; O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan; S-(1,2-Bis(carbethoxy)ethyl) O,O-dimethyl dithiophosphate; NCGC00091902-05; NCGC00091902-08; Malathiozoo; ((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester; Malaphele; Organoderm; S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato; Maltox; Vetiol; S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat; Vegfru malatox; Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle); DSSTox_CID_791; S-(1,2-Bis(ethoxycarbonyl)ethyl) O,O-dimethyl phosphorodithioate; Mercaptotion [Spanish]; Derbac-M; Hilthion 25wdp; Maltox MLT; Diethyl 2-(dimethoxyphosphinothioylthio)succinate; DSSTox_RID_75791; DSSTox_GSID_20791; Latka 4049 [Czech]; Sadofos 30; Kop-Thionkypfosmalacide; Fog 3; [(dimethoxyphosphinothioyl)thio]butanedioic acid diethyl ester; Malathyne; [(Dimethoxyphosphinothioyl)thio]butanedioic acid, diethyl ester; S-(1,O-dimethyl phosphorodithioate; S-[1,O-dimethyl phosphorodithioate; Malathion (USP); OMS 1; IFO 13140; CAS-121-75-5; CCRIS 368; HSDB 665; Ovide (TN); Malathion [USP:BAN]; malathion ,s-(1,2-dicarbethoxyl); diethyl 2-((dimethoxyphosphorothioyl)thio)succinate; EINECS 204-497-7; BRN 1804525; S-[1,2-Bis(carbethoxy)ethyl] O,O-dimethyl dithiophosphate; Gammaxine; Radotion; AI3-17034; S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl phosphorodithioate; Diethyl(dimethoxythiophosphorylthio)succinate; Malathion ULV; Suleo M; Malathion-D10; Diethyl ((dimethoxyphosphinothioyl)thio)butanedioate; Phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate; O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat [Czech]; S-(1,2-Dicarbethoxyethyl) O,O-dimethylphosphorodithioate; Spectrum_001795; ACMC-20n0ay; SpecPlus_000386; O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl) dithiophosphate; O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat [German]; O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan [Polish]; Spectrum2_001228; Spectrum3_000813; Spectrum4_000653; Spectrum5_001936; Diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate; S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat [Dutch]; S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato [Italian]; Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) [French]; S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat [German]; SCHEMBL27358; BSPBio_002305; KBioGR_001025; KBioSS_002288; S-(1,O-dimetil-ditiofosfato; S-1,O-dimethyl thiophosphate; DivK1c_006482; Malathion, analytical standard; Diethyl mercaptosuccinate, O,O-dimethyl thiophosphate; SPBio_001076; S-(1,O-dimethyl-dithiofosfaat; 1,O-dimethyl phosphordithioates; CHEBI:6651; O,2-dikarbetoxylethylditiofosfat; S-(1,O-dimethyl-dithiophasphat; CHEMBL1200468; DTXSID4020791; O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat; BDBM85372; JXSJBGJIGXNWCI-UHFFFAOYSA-; KBio1_001426; KBio2_002286; KBio2_004854; KBio2_007422; KBio3_001805; S-[1,O-dimethyl dithiophosphate; Diethyl mercaptosuccinate, O,O-dimethyl phosphorodithioate; NSC6524; CHEBI:141474; 1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate; Diethyl mercaptosuccinic acid O,O-dimethyl phosphorodithioate; HMS3264A04; Pharmakon1600-00330021; 141318-03-8; HY-B0943; S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat; Malathion 100 microg/mL in Nonane; Tox21_111175; Tox21_400048; CCG-39152; ENT-17034; NSC755848; AKOS015897264; Butanedioic acid, ((dimethoxyphosphinothioyl)-thio)-, diethyl ester, (+-)-; Diethyl (+-)-mercaptosuccinate, S-ester with O,O-dimethyl phosphorodithioate; Diethyl mercaptosuccinic acid, S-ester of O,O-dimethyl phosphorodithioate; Malathion 1000 microg/mL in Toluene; O,2-dicarbethoxyethyl) dithiophosphate; Tox21_111175_1; CS-4416; DB00772; Malathion 10 microg/mL in Cyclohexane; NSC-755848; Malathion 100 microg/mL in Cyclohexane; Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorodithioate; NCGC00091902-01; NCGC00091902-02; NCGC00091902-03; NCGC00091902-06; NCGC00091902-07; NCGC00091902-09; NCGC00091902-11; O,2-dicarbethoxyethyl) phosphorodithioate; AS-13786; CAS_121-75-5; O,2-dicarbethoxyethyl) thiothionophosphate; R319; DB-041629; Dithiophosphate de O,2-dicarboethoxyethyle); FT-0701077; Malathion, vial of 1 g, analytical standard; O,2-di(ethoxycarbamyl)ethyl phosphorothioate; O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl; 0,2-bis(ethoxycarbonyl)ethyl] dithiophosphate; Malathion, PESTANAL(R), analytical standard; C07497; D00534; J10314; K-1631; WLN: 2OV1YVO2 & SPS & O1 & O1; AB00053015_02; diethyl 2-(dimethoxyphosphorothioylthio)succinate; O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl); 121M755; Diethyl (dimethoxyphosphinothioylthio) butanedioate; Diethyl mercaptosuccinate,O-dimethyl thiophosphate; L001138; Q423005; SR-01000942243; Diethyl [(dimethoxyphosphinothoiyl)thio]butanedioate; J-004630; O,O-Dimethyl dithiophosphate diethylmercaptosuccinate; SR-01000942243-1; 1,2-D.(ethoxycarbonyl)dimethyl phosphorothiolothionate; Diethyl mercaptosuccinate,O-dimethyl phosphorodithioate; Malathion, certified reference material, TraceCERT(R); O,O-Dimethyl dithiophosphate of diethyl mercaptosuccinate; 1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphordithioate; Diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]succinate #; Diethyl mercaptosuccinic acid,O-dimethyl phosphorodithioate; Malathion, European Pharmacopoeia (EP) Reference Standard; O,O-Dimethyl S-(1,2-dicarbethoxyethyl) phosphorodithioate; O,O-Dimethyl S-(1,2-dicarbethoxyethyl) thiothionophosphate; O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorothioate; S-(1,2-Dicarbethoxyethyl) O,O-dimethyl phosphorodithioate; Diethyl mercaptosuccinate,O-dimethyl dithiophosphate, S-ester; Malathion, United States Pharmacopeia (USP) Reference Standard; Mercaptosuccinic acid diethyl ester,O-dimethyl phosphorothioate; O,O-dimethyl S-[1,2-bis(ethoxy carbonyl)ethyl]dithiophosphate; o,o-Dimethyl-S-(1,2-di(ethoxycarbonyl)ethyl) phosphorodithioate; S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophasphat; [(DIMETHOXYPHOPHINOTHIOYL)THIO]BUTANEDIOIC ACID, DIETHYL ESTER; Butanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester, (R)-; Diethyl mercaptosuccinate S-ester with O,O-dimethyl phosphorodithioate; Succinic acid, diethyl ester, S-ester with 0,0-dimethyl phosphorodithioate; Succinic acid, diethyl ester, S-ester with O,O-dimethyl phosphorodithioate; 1,4-diethyl 2-{[dimethoxy(sulfanylidene)-$l^{5}-phosphanyl]sulfanyl}butanedioate; Malathion solution, 100 mug/mL in cyclohexane, PESTANAL(R), analytical standard; Mercaptosuccinic acid diethyl ester, S-ester with O,O-dimethyl phosphorothioate; Phosphorodithioic acid,0-dimethyl ester, S-ester with diethyl mercaptosuccinate
Clinical Status
Approved
PubChem CID
4004
Formula
C10H19O6PS2
Canonical SMILES
CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC
InChI
1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3
InChIKey
JXSJBGJIGXNWCI-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 330.4 Topological Polar Surface Area 128
XlogP 2.4 Complexity 341
Heavy Atom Count 19 Rotatable Bond Count 11
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 8
Full List of Drug Formulations (DFMs) Containing This API
          Malathion 0.5% lotion Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Isopropyl Alcohol; Terpineol; Dipentene; Pine Needle Oil
                   Dosage Form Lotion
                   Company Taro Pharm Inds Ltd
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [1]
Alpha-terpineol DIG Info Leukemia AML cells (IC50 = 14000 nM) [2]
References
1 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
2 Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus. Eur J Med Chem. 2018 Sep 5; 157:198-228.

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