Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01346)
Name
Plazomicin
Synonyms    Click to Show/Hide the Synonyms of This API
Plazomicin; ACHN-490; Zemdri; UNII-LYO9XZ250J; LYO9XZ250J; ACHN490; 1154757-24-0; 1154757-24-0 (free); (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[[(2S,3R)-3-amino-6-[(2-hydroxyethylamino)methyl]-3,4-dihydro-2H-pyran-2-yl]oxy]-2-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide; (S)-4-amino-N-((1R,2S,3S,4R,5S)-5-amino-4-(((2R,3R)-3-amino-6-(((2-hydroxyethyl)amino)methyl)-3,4-dihydro-2H-pyran-2-yl)oxy)-2-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide; Plazomicin [USAN:INN]; ACHN 490; Plazomicin (USAN); 6'-(Hydroxylethyl)-1-(haba)-sisomicin; CHEMBL1650559; SCHEMBL11928040; GTPL10847; ZINC68150640; DB12615; D10151; Q15426988; (2S)-4-Amino-N-((1R,2S,3S,4R,5S)-5-amino-4-((2-amino-2,3,4,6-tetradeoxy-6-((2- hydroxyethyl)amino)-alpha-D-glycero-hex-4-enopyranosyl)oxy)-2-((3-deoxy-4-C-methyl-3- (methylamino)-beta-L-arabinopyranosyl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-y; D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-((2-hydroxyethyl)amino)-alpha-D-glycero- hex-4-enopyranosyl-(1->4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L- arabinopyranosyl-(1->6))-N(sup 1)-((2S)-4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-; l]oxy}-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
Clinical Status
Approved
PubChem CID
42613186
Formula
C25H48N6O10
Canonical SMILES
C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC=C(O3)CNCCO)N)N)NC(=O)[C@H](CCN)O)O
InChI
1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1
InChIKey
IYDYFVUFSPQPPV-PEXOCOHZSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=42613186"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 592.7 Topological Polar Surface Area 269
XlogP -6.2 Complexity 873
Heavy Atom Count 41 Rotatable Bond Count 13
Hydrogen Bond Donor Count 11 Hydrogen Bond Acceptor Count 15
Full List of Drug Formulations (DFMs) Containing This API
          Plazomicin 500 mg/10 ml Injection Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Water; Sodium Hydroxide
                   Dosage Form Injection
                   Company Cipla Usa

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