Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01369)
Name
Prucalopride
Synonyms    Click to Show/Hide the Synonyms of This API
Prucalopride; 179474-81-8; Motegrity; UNII-0A09IUW5TP; 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide; 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide; 0A09IUW5TP; C18H26ClN3O3; 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide; CHEMBL117287; R-093877; 179474-81-8 (free base); resotrans; 7-Benzofurancarboxamide, 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-; R093877; Prucalopride [USAN:INN:BAN]; PubChem22481; Prucalopride (USAN/INN); DSSTox_CID_31459; DSSTox_RID_97345; DSSTox_GSID_57670; SCHEMBL16952; GTPL243; cc-249; DTXSID5057670; CHEBI:135552; BCPP000099; HMS3651F04; HMS3748M09; HMS3884P20; BCP02177; EX-A1333; ZINC1891034; Tox21_113885; BDBM50122872; MFCD09837787; s2875; AKOS015951096; AM84628; CCG-268257; DB06480; PB31402; 4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide; NCGC00253867-01; NCGC00253867-02; 4-amino-5-chloro-N-(1-(3-methoxypropyl)-4-piperidinyl)-2,3-dihydro-1-benzofuran-7-carboxamide; AC-23945; AK170477; AS-19549; HY-14151; AB0035840; CAS-179474-81-8; FT-0674128; SW219198-2; Y0251; A11771; A25458; D09205; Q-3828; Q68484; 474P818; L000891; SR-01000945275; SR-01000945275-1; 4-Amino-5+K445-chloro-2,3-dihydro-benzofuran-7-carboxylic acid [1-(3-methoxy-propyl)-piperidin-4-yl]-amide; 4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxylic acid [1-(3-methoxy-propyl)-piperidin-4-yl]-amide
Clinical Status
Approved
PubChem CID
3052762
Formula
C18H26ClN3O3
Canonical SMILES
COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl
InChI
1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChIKey
ZPMNHBXQOOVQJL-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3052762"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 367.9 Topological Polar Surface Area 76.8
XlogP 2 Complexity 445
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Prucalopride 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Colloidal Silicon Dioxide; Lactose Monohydrate; Magnesium Stearate; Microcrystalline Cellulose; Hypromellose; Lactose Monohydrate; Polyethylene Glycol 3000; Titanium Dioxide; Triacetin; Red Iron Oxide; Yellow Iron Oxide; Fd&C Blue 2
                   Dosage Form Tablet
                   Company Takeda Pharmaceuticals America
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [1]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Prucalopride 1 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Colloidal Silicon Dioxide; Lactose Monohydrate; Magnesium Stearate; Microcrystalline Cellulose; Hypromellose; Lactose Monohydrate; Polyethylene Glycol 3000; Titanium Dioxide; Triacetin
                   Dosage Form Tablet
                   Company Takeda Pharmaceuticals America
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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