Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01462)
Name
Tavaborole
Synonyms    Click to Show/Hide the Synonyms of This API
Tavaborole; 174671-46-6; AN-2690; 5-FLUOROBENZO[C][1,2]OXABOROL-1(3H)-OL; AN2690; AN 2690; 2,1-Benzoxaborole, 5-fluoro-1,3-dihydro-1-hydroxy-; UNII-K124A4EUQ3; 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole; 5-fluoro-1-hydroxy-3H-2,1-benzoxaborole; 5-fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol; Kerydin; K124A4EUQ3; CHEBI:77942; MFCD10699483; 5-fluoro-2,1-benzoxaborol-1(3H)-ol; C7H6BFO2; 5-Fluoro-3H-benzo[c][1,2)oxaborol-1-ol; 5-fluoro-3H-benzo[c][1,2]oxaborol-1-ol; Tavaborole [USAN:INN]; Tavaborole (AN-2690); p-fluorbenzoxaborole; Kerydin (TN); Tavaborole (USAN); SCH-900340; AN-2690(Tavaborole); SCHEMBL500016; CHEMBL443052; HSDB 8342; DTXSID00169888; BCP08730; EX-A1086; 3338AH; BDBM50370987; s4996; AKOS006303927; ZINC169990691; CCG-266215; CS-1058; DB09041; DS-8392; MB08883; 5-Fluoro-1-hydroxy-2,1-benzoxaborolane; NCGC00264110-01; NCGC00264110-02; AC-30887; AK163946; HY-10980; SY038332; DB-100333; FT-0697827; X3699; A14999; D10169; W-5454; 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole; Q21011226; 5-Fluoro-1-hydroxyl-1,3-dihydrobenzo[c][1,2]oxaborole; Z1739256284
Clinical Status
Approved
PubChem CID
11499245
Formula
C7H6BFO2
Canonical SMILES
B1(C2=C(CO1)C=C(C=C2)F)O
InChI
1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
InChIKey
LFQDNHWZDQTITF-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11499245"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 151.93 Topological Polar Surface Area 29.5
XlogP N.A. Complexity 155
Heavy Atom Count 11 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Tavaborole 5% solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Alcohol; Edetate Calcium Disodium; Propylene Glycol
                   Dosage Form Solution
                   Company Anacor Pharms
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [1]
References
1 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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