Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01488)
Name
Tioconazole
Synonyms    Click to Show/Hide the Synonyms of This API
tioconazole; 65899-73-2; Vagistat; Trosyl; Vagistat-1; Trosyd; Gyno-trosyd; Fungibacid; Tioconazolum; Zoniden; Tioconazol [INN-Spanish]; Tioconazolum [INN-Latin]; UK-20349; 1-(2-((2-chlorothiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; 1-[2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; UK-20,349; Tioconazol; CHEBI:77898; MFCD00057276; NCGC00167430-01; Tz-3; 1-[(2S)-2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; DSSTox_CID_26619; DSSTox_RID_81771; DSSTox_GSID_46619; New Straitus; 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole; 1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1H-Imidazole, 1-(2-((2-chloro-3-thienyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-; SMR001550005; (+-)-Tioconazole; CAS-65899-73-2; Vagistat-1 (TN); UK 20349; SR-05000001939; EINECS 265-973-8; BRN 0573867; Thioconazole; Tioconazole (JAN/USP/INN); 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1H-Imidazole, 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-; 1-(2,4-Dichloro-beta-((2-chloro-3-thenyl)-oxy)phenethyl)imidazole; (+-)-1-(2,4-Dichloro-beta-((2-chloro-3-ethenyl)oxy)phenethyl)imidazole; Tioconazole, 97%; Tioconazole [USAN:USP:INN:BAN:JAN]; 1-(2,4-Dichloro-(beta-(2-chloro-3-thenyl)oxy)phenethyl)imidazole; (.+/-.)-Tioconazole; SCHEMBL41354; 5-23-04-00324 (Beilstein Handbook Reference); MLS003899209; MLS004712040; MLS006010907; CHEMBL1200438; DTXSID3046619; HMS2090B12; HMS2093P11; HMS3655K22; HMS3712I10; Pharmakon1600-01505581; AMY32535; EBD39607; HY-B0319; Tox21_112434; BDBM50370218; DL-515; KM0968; NSC759169; s1910; AKOS015906500; Tox21_112434_1; CCG-213487; DB01007; KS-5114; NSC-759169; (+-)-1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; NCGC00167430-02; NCGC00167430-03; NCGC00167430-04; AC-13425; AC-31721; AK546825; H949; SBI-0206824.P001; AB0013379; FT-0630756; SW198590-2; C08082; D00890; AB01275523-01; AB01275523_02; AB01275523_03; Tioconazole, VETRANAL(TM), analytical standard; 899T732; A835270; Q260326; SR-05000001939-1; SR-05000001939-2; BRD-A33084557-001-01-7; Tioconazole, United States Pharmacopeia (USP) Reference Standard; 1-[2,4-Dichloro-.beta.-[(2-chloro-3-thenyl)-oxy]phenethyl]imidazole; (.+/-.)-1-(2,4-Dichloro-.beta.-((2-chloro-3-ethenyl)oxy)phenethyl)imidazole; 1-[2-[(2-chloranylthiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole #; 1-[2-[(2-chloro-3-thiophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-[2-[(2-Chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole; Vagistat; Tioconazole for system suitability, European Pharmacopoeia (EP) Reference Standard
Clinical Status
Approved
PubChem CID
5482
Formula
C16H13Cl3N2OS
Canonical SMILES
C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)OCC3=C(SC=C3)Cl
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChIKey
QXHHHPZILQDDPS-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5482"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 387.7 Topological Polar Surface Area 55.3
XlogP 5.3 Complexity 379
Heavy Atom Count 23 Rotatable Bond Count 6
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Tioconazole 6.5% ointment Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated Hydroxyanisole; Magnesium Aluminum Silicate; White Petrolatum
                   Dosage Form Ointment
                   Company Rite Aid Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [1]
References
1 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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