Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01512)
Name
Umeclidinium
Synonyms    Click to Show/Hide the Synonyms of This API
UMECLIDINIUM; UNII-GE2T1418SV; 869185-19-3; Umeclidinium [USAN]; GE2T1418SV; GSK573719; Incruse Ellipta; Umeclidinium (USAN); GSK573719A; diphenyl-[1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]methanol; CHEMBL523299; 1-[2-(benzyloxy)ethyl]-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane; GSK-573719; GTPL7354; SCHEMBL2033192; CHEMBL1187833; CHEBI:79041; DTXSID00235971; BDBM50267614; ZINC34608502; DB09076; NCGC00379061-01; D10180; Q21011235; 1-(2-(Benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)-1-azoniabicyclo(2.2.2)octane; 1-Azoniabicyclo(2.2.2)octane, 4-(hydroxydiphenylmethyl)-1-(2-(phenylmethoxy)ethyl)-; di(phenyl)-[1-[2-(phenylmethoxy)ethyl]-1-azoniabicyclo[2.2.2]octan-4-yl]methanol
Clinical Status
Approved
PubChem CID
11519070
Formula
C29H34NO2+
Canonical SMILES
C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5
InChI
1S/C29H34NO2/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25/h1-15,31H,16-24H2/q+1
InChIKey
FVTWTVQXNAJTQP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11519070"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 428.6 Topological Polar Surface Area 29.5
XlogP 4.7 Complexity 543
Heavy Atom Count 32 Rotatable Bond Count 8
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Umeclidinium eq 62.5mcg base/inh powder Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose Monohydrate (Contains Milk Proteins); Magnesium Stearate
                   Dosage Form Powder
                   Company Glaxo Grp England
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [1]
References
1 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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