Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00034)
Name
Amoxapine
Synonyms    Click to Show/Hide the Synonyms of This API
amoxapine; 14028-44-5; Asendin; Demolox; Moxadil; Amoxan; Desmethylloxapin; Asendis; Amoxapina; Amoxapinum; Amoxepine; Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-; 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine; CL 67772; CL-67772; 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine; UNII-R63VQ857OT; 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine; MFCD00069210; CHEMBL1113; 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine; CL 67,772; MLS000069371; CHEBI:2675; R63VQ857OT; DIBENZ(b,f)(1,4)OXAZEPINE, 2-CHLORO-11-(1-PIPERAZINYL)-; 2-chloro-11-piperazin-1-yldibenzo[b,f][1,4]oxazepine; NCGC00015004-09; Ascendin; SMR000058416; CAS-14028-44-5; DSSTox_CID_2598; Amoxapinum [INN-Latin]; DSSTox_RID_76652; Amoxapina [INN-Spanish]; DSSTox_GSID_22598; (E)-2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine; Asendin (TN); SR-01000003001; EINECS 237-867-1; amoxipine; BRN 0832057; 2-Chlor-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepin; Prestwick_503; Amoxapine [USAN:USP:INN:BAN:JAN]; KS-1197; 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine; Opera_ID_33; Spectrum_000446; CPD000058416; Lopac-A-129; Prestwick0_000102; Prestwick1_000102; Prestwick2_000102; Prestwick3_000102; Spectrum2_001245; Spectrum3_001067; Spectrum4_001218; Spectrum5_001284; Lopac0_000116; REGID_for_CID_2170; SCHEMBL33950; BSPBio_000084; BSPBio_002654; GTPL201; KBioGR_001656; KBioSS_000926; ZINC931; MALEICACIDMONOSODIUMSALT; DivK1c_000236; SPECTRUM2300161; SPBio_001150; SPBio_002023; Amoxapine (JP17/USP/INN); BPBio1_000094; 8-chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine; DTXSID7022598; BDBM22870; HMS500L18; KBio1_000236; KBio2_000926; KBio2_003494; KBio2_006062; KBio3_001874; NINDS_000236; HMS1568E06; HMS2089G10; HMS2093N08; HMS2095E06; HMS2231E13; HMS3259G08; HMS3260G14; HMS3370P03; HMS3712E06; Pharmakon1600-02300161; HY-B0991; Tox21_110064; Tox21_302352; Tox21_500116; ABP000992; CCG-39135; NSC759559; PDSP1_001609; PDSP2_001593; AKOS015895092; Tox21_110064_1; AC-5495; CS-4485; DB00543; LP00116; MCULE-9583761109; NC00546; NSC-759559; SDCCGSBI-0050104.P004; VA10272; IDI1_000236; NCGC00015004-01; NCGC00015004-02; NCGC00015004-03; NCGC00015004-04; NCGC00015004-05; NCGC00015004-06; NCGC00015004-07; NCGC00015004-08; NCGC00015004-10; NCGC00015004-11; NCGC00015004-13; NCGC00015004-16; NCGC00015004-22; NCGC00023887-03; NCGC00023887-04; NCGC00023887-05; NCGC00023887-06; NCGC00255124-01; NCGC00260801-01; SBI-0050104.P003; AK01050722; EU-0100116; FT-0659871; FT-0662122; A16406; D00228; Q58356; AB00052421-13; AB00052421_14; AB00052421_15; 028A445; A807639; L001293; J-007373; SR-01000003001-2; SR-01000003001-4; SR-01000003001-6; 8-chloro-6-piperazin-1-ylbenzo[b][1,5]benzoxazepine; BRD-K02265150-001-05-9; BRD-K02265150-001-15-8; 2-Chloro-11-(1-piperazinyl)dibenz[b,f]-1,4-oxazepine; 2-Chloro-11-(1-piperazinyl)dibenzo[b,f]-1,4-oxazepine; 2-Chloro-11-piperazin-1-yl-dibenzo[b,f][1,4]oxazepine; 8-chloro-6-(1-piperazinyl)benzo[b][1,4]benzoxazepine; Z1551429736; 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine #; 8-chloranyl-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine; Amoxapine, 1.0 mg/mL in methanol, certified reference material; Amoxapine, United States Pharmacopeia (USP) Reference Standard; Dibenzo[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-; Amoxapine, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status
Approved
Disease Indication Major depressive disorder ICD-11: 6A70 [1]
PubChem CID
2170
Formula
C17H16ClN3O
Canonical SMILES
C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
InChI
1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChIKey
QWGDMFLQWFTERH-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2170"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 313.8 Topological Polar Surface Area 36.9
XlogP 2.6 Complexity 424
Heavy Atom Count 22 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Amoxapine 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c blue no. 2; Magnesium stearate; Anhydrous dibasic calcium phosphate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Amoxapine 150 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Magnesium stearate; Anhydrous dibasic calcium phosphate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Amoxapine 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Magnesium stearate; Anhydrous dibasic calcium phosphate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Magnesium stearate; Dibasic calcium phosphate dihydrate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Amoxapine 25 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Anhydrous dibasic calcium phosphate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved amoxapine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

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