Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00041)
Name	Apremilast
Synonyms	Click to Show/Hide the Synonyms of This API Apremilast; 608141-41-9; OTEZLA; CC-10004; CC 10004; Apremilast (CC-10004); CC10004; UNII-UP7QBP99PN; (S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide; CHEBI:78540; UP7QBP99PN; CHEMBL514800; N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide; (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione; C22H24N2O7S; Apremilast [USAN:INN]; apremilastum; MFCD18782607; HSDB 8221; Otezla (TN); Apremilast (JAN/USAN); Apremilast/CC 10004/; SCHEMBL302992; GTPL7372; EX-A336; QCR-202; cas:608141-41-9;Apremilast; AOB87775; BCP03783; BCP25283; BDBM50248919; ZINC30691736; AKOS016339660; BCP9000311; CCG-269336; CS-0671; DB05676; FK-0727; SB16492; AC-27650; HY-12085; BCP0726000109; AB0093139; SW219856-1; A11289; D08860; S-7765; Q2858961; UNII-N5UK68MGDZ component IMOZEMNVLZVGJZ-QGZVFWFLSA-N; (+)-N-(2-((1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxo- 2,3-dihydro-1H-isoindol-4-yl)acetamide; (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione(Apremilast); (S)-N-{2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide; 4-[[5 pound not7-dihydroxy-2 pound not2-dimethyl-8-(2-methylpropanoyl)chromen-6-yl]methy l]-3 pound not5-dihydroxy-6 pound not6-dimethyl-2-(2-methylpropanoyl)cyclohexa-2 pound not4-dien- 1-one; Acetamide, N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-; N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide; N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide; N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
Clinical Status	Approved
Disease Indication	Psoriasis vulgaris		ICD-11: EA90	[1]
PubChem CID	11561674
Formula	C22H24N2O7S
Canonical SMILES	CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
InChI	1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
InChIKey	IMOZEMNVLZVGJZ-QGZVFWFLSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11561674"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	460.5	Topological Polar Surface Area	128
	XlogP	1.8	Complexity	825
	Heavy Atom Count	32	Rotatable Bond Count	8
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	7

Full List of Drug Formulations (DFMs) Containing This API
Apremilast 30 mg tablet			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
Dosage Form	Oral Tablet
Company	Celgene Corporation
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[2]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[2]

References
1	FDA label for approved apremilast from the official website of the U.S. Food and Drug Administration.
2	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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