Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00076)
Name
Brexpiprazole
Synonyms    Click to Show/Hide the Synonyms of This API
BREXPIPRAZOLE; 913611-97-9; OPC-34712; 7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one; OPC 34712; UNII-2J3YBM1K8C; 2J3YBM1K8C; 7-(4-(4-(1-Benzothiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one; 7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]-1H-quinolin-2-one; Rexulti; Brexpiprazole [USAN:INN]; Rxulti; Rexulti (TN); Brexpiprazole.2H2O; Brexpiprazole(OPC34712); Brexpiprazole; OPC-34712; GTPL7672; SCHEMBL1037592; Brexpiprazole (JAN/USAN/INN); CHEMBL2105760; SCHEMBL14772509; DTXSID40238527; CHEBI:134716; HMS3885P12; BCP10218; BCP24077; EX-A2639; OPC34712; MFCD27987920; ZINC84758479; AKOS025291100; CCG-269055; DB09128; SB16735; NCGC00378574-01; NCGC00378574-02; AC-30404; AK171366; AS-56467; DA-35913; HY-15780; FT-0712292; A13527; D10309; Q2924764; 2(1H)-Quinolinone, 7-(4-(4-benzo(b)thien-4-yl-1-piperazinyl)butoxy)-; 7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl)butoxy]- 2(1H)-Quinolinone; 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)-butoxy]-1H-quinolin-2-one; 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one; 7-[4-(4-Benzo[b]thiophen-4-ylpiperazin-1-yl)butoxy]-1H-quinolin-2-one
Clinical Status
Approved
Disease Indication Bipolar disorder ICD-11: 6A60 [1]
PubChem CID
11978813
Formula
C25H27N3O2S
Canonical SMILES
C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4
InChI
1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29)
InChIKey
ZKIAIYBUSXZPLP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11978813"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 433.6 Topological Polar Surface Area 73
XlogP 4.7 Complexity 636
Heavy Atom Count 31 Rotatable Bond Count 7
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Brexpiprazole 0.25 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Low-substituted hydroxypropyl cellulose, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Otsuka America Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Brexpiprazole 0.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Low-substituted hydroxypropyl cellulose, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Otsuka America Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Brexpiprazole 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Low-substituted hydroxypropyl cellulose, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Otsuka America Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Brexpiprazole 3 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Low-substituted hydroxypropyl cellulose, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Otsuka America Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Brexpiprazole 1 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Low-substituted hydroxypropyl cellulose, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Otsuka America Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Brexpiprazole 4 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Low-substituted hydroxypropyl cellulose, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Otsuka America Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved brexpiprazole from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.