Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00092)
Name
Calcium gluconate
Synonyms    Click to Show/Hide the Synonyms of This API
CALCIUM GLUCONATE; 299-28-5; Calcium D-gluconate; D-Gluconic acid, calcium salt (2:1); Gluconate Calcium; UNII-SQE6VB453K; Glucobiogen; Calciofon; Calcium gluconate anhydrous; Gluconic Acid Calcium Salt; SQE6VB453K; Calglucon; Ebucin; MFCD00064209; Gluconate de calcium; Almora; Calcicol; Calcipur; Calglucol; Dragocal; Kalpren; Novocal; Calcium hexagluconate; calcium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate; D-Gluconic acid, calcium salt, 99%; Calcium D-gluconate, anhydrous; Gluconato di calcio; Calcium D-gluconate (1:2); Gluconate de calcium [French]; Gluconato di calcio [Italian]; CCRIS 1336; HSDB 994; Calcium Gluconate [USAN:JAN]; EINECS 206-075-8; Gluconic acid, calcium salt; Gluconic acid, calcium salt (2:1), D-; 2,3,4,5,6-Pentahydroxycaproic Acid hemicalcium salt; Calcarea gluconica; Gluconic acid, calcium salt, D-; Calcium di-gluconate; calcium bis(D-gluconate); Calcium gluconate (USP); Calcium gluconate, anhydrous; SCHEMBL24132; CHEBI:3309; INS NO.578; Boron Gluconate Blend 5% 40M; CHEMBL2106119; DTXSID2029618; INS-578; AKOS015895893; DB11126; C08133; D00935; Q413739; W-202243; Calcium D-gluconate gel, 2.5% w/w Aqueous Solution; calcium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate]; calcium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate;(2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoate
Clinical Status
Approved
Disease Indication Vitamin deficiency ICD-11: 5B55 [1]
PubChem CID
9290
Formula
C12H22CaO14
Canonical SMILES
C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Ca+2]
InChI
1S/2C6H12O7.Ca/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
InChIKey
NEEHYRZPVYRGPP-IYEMJOQQSA-L
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=9290"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 430.37 Topological Polar Surface Area 283
XlogP N.A. Complexity 165
Heavy Atom Count 27 Rotatable Bond Count 8
Hydrogen Bond Donor Count 10 Hydrogen Bond Acceptor Count 14
Full List of Drug Formulations (DFMs) Containing This API
          Calcium gluconate 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved calcium gluconate from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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