Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00099)
Name
Carbinoxamine maleate
Synonyms    Click to Show/Hide the Synonyms of This API
CARBINOXAMINE MALEATE; 3505-38-2; Carbinoxamine maleate salt; Lergefin; Ciberon; Clistin; Cliston; p-Carbinoxamine maleate; Allergefon maleate; Paracarbinoxamine maleate; Carbinoxamine hydrogen maleate; C20H23ClN2O5; CHEBI:31353; 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine maleate; 3505-38-2 (Carbinoxamine Maleate); Hislosine; Ziriton; Histine sirup; Polistin T-caps; 2-((4-chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethan-1-amine maleate; Polistine T-caps; DSSTox_CID_27805; DSSTox_RID_82573; Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-,(2Z)-2-butenedioate (1:1); DSSTox_GSID_47828; Arbinoxa; Clistine Maleate; Clistin-D; Karbinal ER; (Z)-but-2-enedioic acid;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine; component of Clistin-D; SR-01000736676; NCGC00166141-01; EINECS 222-498-0; NSC 62362; Clistin maleate; 2-[p-Chloro-alpha-[2-(dimethylamino)ethoxy]benzyl]pyridine maleate; Carbinoxamine maleate [USP:JAN]; Prestwick_238; arbinoxaMine Maleate; Clistin (TN); Karbinal er (TN); 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine maleate; 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine bimaleate; 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine maleate (1:1); CAS-3505-38-2; Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-, (Z)-2-butenedioate (1:1); SCHEMBL97703; SPECTRUM1500161; CHEMBL1200974; DTXSID0047828; HMS502I21; HY-B1589A; Carbinoxamine maleate (JAN/USP); HMS1570B03; HMS1920I21; HMS2091A04; HMS2097B03; HMS3259G22; HMS3714B03; HMS3885F18; Pharmakon1600-01500161; BCP28449; NSC62362; Tox21_112336; CCG-40113; MFCD00082461; NSC-62362; NSC756670; WLN: QV1U1VQ -C &621; AKOS015962162; Tox21_112336_1; AC-5508; CS-8018; NC00602; NSC-756670; Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-, maleate (1:1); NCGC00095302-01; NCGC00166141-06; Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); Carbinoxamine maleate salt, analytical standard; D01336; A822512; Ethanamine,N-dimethyl-, (Z)-2-butenedioate (1:1); SR-01000736676-2; SR-01000736676-3; Q27114280; 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-ethanamin(z)-2-bute; 2-[p-Chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine bimaleate; 2-[p-Chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine maleate; Carbinoxamine maleate, United States Pharmacopeia (USP) Reference Standard; (Z)-2-butenedioic acid; 2-[(4-chlorophenyl)-(2-pyridinyl)methoxy]-N,N-dimethylethanamine; (Z)-but-2-enedioic acid; 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine; 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine (2Z)-but-2-enedioate; Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N, N-dimethyl-, (Z)-2-butenedioate
Clinical Status
Approved
Disease Indication Allergic rhinitis ICD-11: CA08 [1]
PubChem CID
5282409
Formula
C20H23ClN2O5
Canonical SMILES
CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\\C(=O)O)\\C(=O)O
InChI
1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
GVNWHCVWDRNXAZ-BTJKTKAUSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5282409"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 406.9 Topological Polar Surface Area 100
XlogP N.A. Complexity 386
Heavy Atom Count 28 Rotatable Bond Count 8
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Carbinoxamine maleate 4 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical; Mikart
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Biocomp Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Creekwood Pharmaceuticals; Pamlab
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Boca Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Cypress Pharmaceutical; Hawthorn Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Carbinoxamine maleate 6 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Carwin Pharmaceutical Associates; Mikart
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Foxland Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved carbinoxamine maleate from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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