Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00102)
Name
Carprofen
Synonyms    Click to Show/Hide the Synonyms of This API
carprofen; 53716-49-7; 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid; Rimadyl; Imadyl; Ridamyl; Carprofene; Carprofeno; Carprofenum; Carprofene [INN-French]; Carprofenum [INN-Latin]; 6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid; Carprofeno [INN-Spanish]; 6-Chloro-alpha-methylcarbazole-2-acetic acid; Ro 20-5720/000; Carprofen-d3; (+-)-6-Chloro-alpha-methylcarbazole-2-acetic acid; 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid; MFCD00079028; CHEMBL1316; (+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid; CHEBI:364453; NSC297935; NCGC00094937-01; Carprodyl; Carprofeno [Spanish]; Ro-205720000; 2-(6-chloro-9H-carbazol-2-yl)-3,3,3-trideuteriopropanoic acid; DSSTox_CID_25871; DSSTox_RID_81189; DSSTox_GSID_45871; (.+-.)-6-Chloro-.alpha.-methylcarbazole-2-acetic acid; Carpaquin; Norocarp; Ro 20-5720; SMR000718633; Rimadyl (TN); C 5720; CAS-53716-49-7; CCRIS 3507; SR-01000837515; EINECS 258-712-4; NSC 297935; BRN 0487098; Carprofen [USAN:USP:INN:BAN]; PubChem9953; 52263-47-5; Ro-20-5720; Carprofen (USP/INN); Spectrum2_001236; Spectrum3_000939; Spectrum4_001038; Spectrum5_001802; Ro-20-5720/000; SCHEMBL3909; (+-)-6-Chlor-alpha-methyl-2-carbazolessigsaeure; KBioGR_001595; 5-22-03-00391 (Beilstein Handbook Reference); MLS001201778; MLS001306441; SPECTRUM1502006; SPBio_001112; GTPL7141; 9H-Carbazole-2-acetic acid, 6-chloro-.alpha.-methyl-; Carprofen, >=97% (HPLC); DTXSID1045871; KBio3_001978; HMS1921D04; HMS2092B16; HMS2234P15; HMS3652E20; HMS3715F09; HMS3748C07; HMS3885F07; Pharmakon1600-01502006; ACT03356; HY-B1227; Tox21_111363; 9H-Carbazole-2-acetic acid, 6-chloro-.alpha.-methyl-, (.+-.)-; 9H-CARBAZOLE-2-ACETIC ACID, 6-CHLORO-alpha-METHYL-, (+-)-; BBL009935; BDBM50097346; CCG-39146; NSC758154; STK711093; 9H-Carbazole-2-acetic acid, (-)-; AKOS005530663; Tox21_111363_1; AC-1266; CS-4875; DB00821; KS-1163; LS41073; MCULE-9476030813; NE55949; NSC-297935; NSC-758154; NCGC00094937-02; NCGC00094937-04; NCGC00094937-05; 9H-Carbazole-2-acetic acid, (.+-.)-; AK343600; SBI-0052885.P002; AB0012886; FT-0602833; FT-0664393; FT-0664394; FT-0664395; SW199610-3; 6-chloro-alpha-methyl-carbazole-2-acetic acid; Carprofen, VETRANAL(TM), analytical standard; C18364; D03410; J10272; 2-(6-chloranyl-9H-carbazol-2-yl)propanoic acid; AB00876263_06; AB00876263_07; 716C497; A829748; Q905755; (+/-)-6-Chloro-alpha-methylcarbazole-2-aceticacid; SR-01000837515-2; SR-01000837515-3; (+/-)-6-Chloro-alpha-methylcarbazole-2-acetic acid; BRD-A17411484-001-05-1; Z1814381791; 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid(carprofen); Carprofen, European Pharmacopoeia (EP) Reference Standard; 9H-Carbazole-2-acetic acid, 6-chloro-.alpha.-methyl-, (-)-; Carprofen, United States Pharmacopeia (USP) Reference Standard; Carprofen, Pharmaceutical Secondary Standard; Certified Reference Material; Carprofen for system suitability, European Pharmacopoeia (EP) Reference Standard
Clinical Status
Approved
Disease Indication Anaesthesia ICD-11: 8E22 [1]
PubChem CID
2581
Formula
C15H12ClNO2
Canonical SMILES
CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O
InChI
1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19)
InChIKey
PUXBGTOOZJQSKH-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2581"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 273.71 Topological Polar Surface Area 53.1
XlogP 4 Complexity 362
Heavy Atom Count 19 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Carprofen 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c yellow no. 6; Magnesium stearate; Water; Croscarmellose sodium; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Putney; Vedco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Vetoquinol
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company TruRx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
          Carprofen 25 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c yellow no. 6; Magnesium stearate; Water; Croscarmellose sodium; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Putney; Vedco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Vetoquinol
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company TruRx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
          Carprofen 75 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c yellow no. 6; Magnesium stearate; Water; Croscarmellose sodium; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Putney; Vedco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Vetoquinol
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company TruRx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
References
1 FDA label for approved carprofen from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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