Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00137)
Name
Clobazam
Synonyms    Click to Show/Hide the Synonyms of This API
Clobazam; Frisium; Urbanyl; Chlorepin; Clorepin; 22316-47-8; Urbadan; LM-2717; HR 376; Clobazamum; LM 2717; RU-4723; H-4723; H 4723; 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione; UNII-2MRO291B4U; 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl-; 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione; NSC 336279; 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine; CHEBI:31413; HR-376; 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione; 2MRO291B4U; NSC336279; NSC-336279; NCGC00168249-01; Caastilium; Noiafren; Urbanil; Odipam; Clobazamum [INN-Latin]; Clobazepam; 7-Chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione; 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione; 7-chloro-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione; Mystan (TN); CCRIS 7506; EINECS 244-908-7; BRN 0758410; Clobazam (JAN/USAN/INN); Clobazam [USAN:INN:BAN]; Perizam; Tapclob; Urbanol; DEA No. 2751; Clobazepam; Frisium; Onfi (TN); 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine; DSSTox_CID_26759; DSSTox_RID_81883; DSSTox_GSID_46759; SCHEMBL43038; 5-24-08-00034 (Beilstein Handbook Reference); MLS003899217; CHEMBL70418; GTPL7149; ZINC1175; DTXSID2046759; HSDB 8343; Clobazam 0.1 mg/ml in Methanol; Clobazam 1.0 mg/ml in Methanol; HY-A0041; Tox21_112608; BDBM50247888; AKOS025401921; CS-6756; DB00349; SMR000058811; WLN: T67 GNV JVN IHJ CG G1 KR; CAS-22316-47-8; DB-045870; D01253; Q412164; SR-01000937603; SR-01000937603-2; 7-Chloro-1-methyl-5-phenyl-1H-1,4(3H,5H)-dione; 7-Chloro-1-methyl-5-phenyl-1H-1,4-(3H,5H)-dione; 1H-1,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl-; 1-phenyl 5-methyl 8-chloro 1,2,4,5-tetrahydo 2,4-dioxo 3H-1,5-benzodiazepine; 1-phenyl 5-methyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine; 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1, 5-benzodiazepine; 1-Phenyl-5-methyl-8-chloro-1,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine; Clobazam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
Clinical Status
Approved
Disease Indication Lennox-gastaut syndrome ICD-11: 8A62 [1]
PubChem CID
2789
Formula
C16H13ClN2O2
Canonical SMILES
CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
InChI
1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
InChIKey
CXOXHMZGEKVPMT-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2789"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 300.74 Topological Polar Surface Area 40.6
XlogP 2.1 Complexity 423
Heavy Atom Count 21 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Clobazam 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Lundbeck Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Clobazam 20 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Lundbeck Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved clobazam from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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