Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00150)
Name
Colesevelam
Synonyms    Click to Show/Hide the Synonyms of This API
Welchol; Colesevelam HCl; 2-(chloromethyl)oxirane;prop-2-en-1-amine;N-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;chloride;hydrochloride; GT 31-104HB; UNII-P4SG24WI5Q; GT-31104; GT 31-104; Colesevelam hydrochloride [USAN]; P4SG24WI5Q; GT31-104HB; Cholestagel, Colesevelam hydrochloride; HS-0084; 1-Hexaminium, N,N,N-trimethyl-6-(2-propenylamino)-, chloride, polymer with (chloromethyl)oxirane, 2-propen-4-amine and N-2-propenyl-1-decanamine, hydrochloride; 2-Propen-1-amine polymer with (chloromethyl)oxirane, N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride, and N-2-propenyl-1-decanamine, hydrochloride; Allylamine polymer with 1-chloro-2,3-epoxypropane, (6-(allylamino)hexyl)trimethylammonium chloride and N-allyldecylamine, hydrochloride; FT-0697863; AB01563397_01; Q899036
Clinical Status
Approved
Disease Indication Hypertriglyceridaemia ICD-11: 5C80 [1]
PubChem CID
160051
Formula
C31H67Cl3N4O
Canonical SMILES
CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C.C=CCN.C1C(O1)CCl.Cl.[Cl-]
InChI
1S/C13H27N.C12H27N2.C3H5ClO.C3H7N.2ClH/c1-3-5-6-7-8-9-10-11-13-14-12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4;;/h4,14H,2-3,5-13H2,1H3;5,13H,1,6-12H2,2-4H3;3H,1-2H2;2H,1,3-4H2;2*1H/q;+1;;;;/p-1
InChIKey
VTAKZNRDSPNOAU-UHFFFAOYSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=160051"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 618.2 Topological Polar Surface Area 62.6
XlogP N.A. Complexity 301
Heavy Atom Count 39 Rotatable Bond Count 22
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Colesevelam 625 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (15000 mpa.s)
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved colesevelam from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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