Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00191)
Name
Dichlorphenamide
Synonyms    Click to Show/Hide the Synonyms of This API
dichlorphenamide; Diclofenamide; 120-97-8; 4,5-dichlorobenzene-1,3-disulfonamide; Dichlofenamide; Dichlorophenamide; Daranide; Antidrasi; Dichlorphenamid; Glauconide; Glaucol; Oratrol; 1,3-Benzenedisulfonamide, 4,5-dichloro-; Diclofenamida; Diclofenamidum; 4,5-Dichloro-m-benzenedisulfonamide; 1,3-Disulfamyl-4,5-dichlorobenzene; Diclofenamidum [INN-Latin]; 1,3-Disulfamoyl-4,5-dichlorobenzene; 4,5-Dichloro-1,3-disulfamoylbenzene; Diclofenamida [INN-Spanish]; 3,4-Dichloro-5-sulfamylbenzenesulfonamide; Keveyis; 4,5-Dichloro-1,3-benzenedisulfonamide; CB 8000; UNII-VVJ6673MHY; m-Benzenedisulfonamide, 4,5-dichloro-; Dichlorphenamide (USP); Dichlorphenamide [USP]; CHEMBL17; Diclofenamid; VVJ6673MHY; Barastonin; Dichlorphenamide (Diclofenamide); Glajust; Glaumid; Glafco; CHEBI:101085; 4,5-Dichloro-benzene-1,3-disulfonic acid diamide; NCGC00016371-01; CAS-120-97-8; Dasanide; Daranide (TN); HSDB 3267; 120D978; Dichlorophenamide (DCP); EINECS 204-440-6; BRN 2703329; sulfonamide 4; 4,5-Dichloro-m-benzendisulfonamide; Keveyis (TN); Prestwick_1071; Diclofenamide [INN]; Dichlorophenamide, DCP; PubChem22279; Prestwick0_000809; Prestwick1_000809; Prestwick2_000809; Prestwick3_000809; Diclofenamide (JAN/INN); DSSTox_CID_2922; DSSTox_RID_76789; DSSTox_GSID_22922; BSPBio_000677; MLS002154010; SCHEMBL112376; SPBio_002598; BPBio1_000745; GTPL6807; DTXSID1022922; BDBM10883; HMS1570B19; HMS2097B19; HMS2236I07; HMS3373G04; HMS3655H06; HMS3714B19; HMS3745K19; ZINC896918; BCP22591; EX-A1311; HY-B0397; Tox21_110401; MFCD00148948; RW3382; SBB058142; AKOS015899860; CCG-220809; DB01144; MCULE-4570158631; 4,5-Dicholorobenzene-1,3-disulfonamide; NCGC00016371-02; NCGC00016371-04; NCGC00016371-05; NCGC00016371-06; NCGC00016371-08; AC-25007; AS-63955; SMR001233338; 4,5-Dichloro-1,3-benzenedisulfonamide #; AB0108325; FT-0648264; ST51014977; SW197138-3; A21072; C07459; D00518; SR-01000841825; Q3706987; SR-01000841825-2; W-108466; BRD-K71499074-001-03-8; Dichlorphenamide, United States Pharmacopeia (USP) Reference Standard; Diclofenamide; Dichlofenamide; Daranide; 4,5-dichlorobenzene-1,3-disulfonamide
Clinical Status
Approved
Disease Indication Glaucoma ICD-11: 9C61 [1]
PubChem CID
3038
Formula
C6H6Cl2N2O4S2
Canonical SMILES
C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N
InChI
1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
InChIKey
GJQPMPFPNINLKP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3038"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 305.2 Topological Polar Surface Area 137
XlogP 0.3 Complexity 452
Heavy Atom Count 16 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Dichlorphenamide 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Magnesium stearate; Aluminum oxide
                   Dosage Form Oral Tablet
                   Company Taro Pharmaceuticals USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Strongbridge US; Taro Pharmaceuticals USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 Dichlorphenamide: A Review in Primary Periodic Paralyses. Drugs. 2016 Mar;76(4):501-7.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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