Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00206)
Name
Disulfiram
Synonyms    Click to Show/Hide the Synonyms of This API
disulfiram; Tetraethylthiuram disulfide; 97-77-8; Antabuse; Antabus; Bis(diethylthiocarbamoyl) disulfide; Alcophobin; Anticol; Esperal; Teturam; Dicupral; Exhorran; Ethyldithiurame; Abstensil; Antaethyl; Antietanol; Antivitium; Contralin; Tetradine; Tetraetil; Teturamin; Abstinil; Abstinyl; Antadix; Antalcol; Antetan; Antetil; Antietil; Antikol; Aversan; Averzan; Cronetal; Krotenal; Refusal; Etabus; Ethyl tuads; Ethyl Thiram; Ethyl Thiurad; Ethyl Tuex; Antaenyl; Antaetil; Antiaethan; Contrapot; Disulfan; Disulfuram; Ephorran; Stopetyl; Thiuranide; Anteyl; Bonibal; Disetil; Nocbin; Tenurid; Tenutex; Tetidis; Ekagom TEDS; Ekagom TETDS; Ethyldithiourame; Anti-ethyl; Alk-aubs; Thiuram E; Soxinol TET; Tetraethylthiram disulfide; Ekagom DTET; Accel TET; Espenal; Exhoran; Sanceler TET-G; Ro-sulfiram; Tetraethylthiuram disulphide; Tetraethylthiuram; Tuads, ethyl; Usaf B-33; Sanceler TET; Tetraethylthioperoxydicarbonic diamide; Stopaethyl; Thireranide; Antaethan; Antethyl; Tetradin; Tillram; Accel TET-R; Ethyl Thiudad; Dupon 4472; Tetraethylthiuran disulfide; Anthethyl; Disulphuram; Dupont fungicide 4472; Hocakrotenalnci-C02959; Tetraethylthiram disulphide; Bis(diethylthiocarbamyl) disulfide; Tetraethylthiuram sulfide; Thiuram disulfide, tetraethyl-; N,N,N',N'-Tetraethylthiuram disulfide; Antabuse (TN); Bis(N,N-diethylthiocarbamoyl) disulfide; C10H20N2S4; 1,1'-Dithiobis(N,N-diethylthioformamide); Disulfide, bis(diethylthiocarbamoyl); ENT 27,340; NSC 190940; UNII-TR3MLJ1UAI; Thioperoxydicarbonic diamide, tetraethyl-; Bis(diethylthiocarbamoyl)disulphide; NCI-C02959; diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate; MFCD00009048; Bis(N,N-diethylthiocarbamoyl)disulphide; N,N,N',N'-Tetraethylthiuram disulphide; Bis((diethylamino)thioxomethyl)disulphide; Bis((diethylamino)thioxomethyl) disulfide; Tetraethylthiuram disulfide;TETD; Disulfiram (Antabuse); TR3MLJ1UAI; NSC-25953; Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl-; CHEMBL964; MLS000069818; CHEBI:4659; Bis(diethylthiocarbamyoyl)disulfide; 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane; NSC25953; Esperal [France]; CAS-97-77-8; N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide; NCGC00016000-08; NCGC00016000-13; SMR000059171; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-; DSSTox_CID_1322; Ancazide ET; Akrochem TETD; Perkacit TETD; Ekaland TETD; Perkait TETD; DSSTox_RID_76082; DSSTox_GSID_21322; Ethyl Tuads Rodform; Tetraethylthiuram disulfide, 97%; 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)-nitrilo]}tetraethane; Disulfiramum [INN-Latin]; Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetraethyl-; Disulfiramo [INN-Spanish]; Bis[(diethylamino)thioxomethyl] disulfide; CCRIS 582; 1,1'-Dithiobis[N,N-diethylthioformamide]; HSDB 3317; SR-01000076145; EINECS 202-607-8; NSC 25953; Disulfarim; AI3-27340; Formamide, 1,1'-dithiobis(N,N-diethylthio-; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetraethyl-; Disulfiram [USP:INN:BAN:JAN]; Prestwick_182; Spectrum_001010; CPD000059171; Opera_ID_224; Prestwick0_000097; Prestwick1_000097; Prestwick2_000097; Prestwick3_000097; Spectrum2_001176; Spectrum3_000405; Spectrum4_000228; Spectrum5_001590; Lopac-T-1132; 1,N-diethylthioformamide]; Formamide, 1,1'-dithiobis(N,N-diethylthio)-; UPCMLD-DP090; EC 202-607-8; T 1132; tetraethyl thiuram disulfide; Tetraethyldithiuram disulfide; Lopac0_001164; SCHEMBL27213; BSPBio_000054; BSPBio_001930; KBioGR_000895; KBioSS_001490; MLS000758264; MLS001076475; MLS001423963; ARONIS24121; SPECTRUM1500262; SPBio_001191; SPBio_001993; ACMC-209s92; BPBio1_000060; Disulfiram (JP17/USP/INN); GTPL7168; ORA102; DTXSID1021322; UPCMLD-DP090:001; KBio2_001490; KBio2_004058; KBio2_006626; KBio3_001150; ORA-102; Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl-; HMS1568C16; HMS1920I16; HMS2051M17; HMS2090C18; HMS2091O22; HMS2095C16; HMS2230K06; HMS3263J09; HMS3371B21; HMS3393M17; HMS3655I19; HMS3712C16; HMS3867H13; Pharmakon1600-01500262; BCP07331; HY-B0240; ZINC1529266; bis-(diethyl-thiocarbamyl)-disulfide; Tox21_110280; Tox21_300403; Tox21_400072; Tox21_501164; ANW-40884; BDBM50058655; CCG-39549; DL-379; N,N',N'-Tetraethylthiuram disulfide; NSC756748; NSC800739; SBB058706; STL069539; AKOS000120201; Tox21_110280_1; DB00822; HS-0057; LP01164; MCULE-1443050857; NC00063; NSC-756748; NSC-800739; SDCCGSBI-0051131.P005; WLN: 2N2 & YUS & S 2; NCGC00016000-01; NCGC00016000-02; NCGC00016000-03; NCGC00016000-04; NCGC00016000-05; NCGC00016000-06; NCGC00016000-07; NCGC00016000-09; NCGC00016000-10; NCGC00016000-11; NCGC00016000-12; NCGC00016000-14; NCGC00016000-15; NCGC00016000-18; NCGC00016000-29; NCGC00094423-01; NCGC00094423-02; NCGC00094423-03; NCGC00094423-05; NCGC00094423-06; NCGC00094423-07; NCGC00254447-01; NCGC00261849-01; N,N,N'',N''-tetraethylthiuram disulfide; Formamide,1'-dithiobis(N,N-diethylthio)-; SBI-0051131.P004; 1,1''-dithiobis(N,N-diethylthioformamide); DB-057683; AB00051976; EU-0101164; FT-0631502; FT-0667720; SW196492-4; Tetraethylthiuram disulfide, >=97.0% (S); C01692; D00131; S00294; Z-0809; AB00051976-20; AB00051976-21; AB00051976-23; AB00051976_22; AB00051976_25; A845750; Q409665; Q-201812; SR-01000076145-1; SR-01000076145-5; SR-01000076145-8; BRD-K32744045-001-05-6; BRD-K32744045-001-17-1; Z1522553469; Disulfiram, British Pharmacopoeia (BP) Reference Standard; Disulfiram, European Pharmacopoeia (EP) Reference Standard; 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetra; Disulfiram, United States Pharmacopeia (USP) Reference Standard; (diethylamino){[(diethylamino)thioxomethyl]disulfanyl}methane-1-thione; 1,1'',1'''',1''''''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane; Disulfiram, Pharmaceutical Secondary Standard; Certified Reference Material; N,N-diethylcarbamodithioic acid [[diethylamino(sulfanylidene)methyl]thio] ester
Clinical Status
Approved
Disease Indication Alcohol dependence ICD-11: 6C40 [1]
PubChem CID
3117
Formula
C10H20N2S4
Canonical SMILES
CCN(CC)C(=S)SSC(=S)N(CC)CC
InChI
1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
InChIKey
AUZONCFQVSMFAP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3117"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 296.5 Topological Polar Surface Area 121
XlogP 3.9 Complexity 201
Heavy Atom Count 16 Rotatable Bond Count 7
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Disulfiram 250 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals; Teva Women's Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Alvogen; Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Croscarmellose sodium; Poloxamer 188; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Povidones
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Disulfiram 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals; Teva Women's Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Croscarmellose sodium; Poloxamer 188; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Crospovidone, unspecified; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved disulfiram from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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