Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00228) | |||||
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Name |
Emtricitabine
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Synonyms |
Click to Show/Hide the Synonyms of This API
Emtricitabine; 143491-57-0; Emtriva; Coviracil; (-)-FTC; 524W91; BW-524W91; Racivir; BW524W91; (-)-2'-Deoxy-5-fluoro-3'-thiacytidine; UNII-G70B4ETF4S; 143491-54-7; BW 524W91; (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine; CHEBI:31536; FTC-(-); 5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine; G70B4ETF4S; Emtritabine; MFCD00870151; 2',3'-Dideoxy-5-fluoro-3'-thiacytidine; NCGC00164564-01; (-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; PSI 5004; Coviracil(TM); DRG-0208; Emtriva(TM); Emtricitabine (Emtriva); SMR002533604; BW 1592; 2',3',5-FTC; HSDB 7337; FTC, (-)-; Emtricitabine [USAN:INN]; (-)-.beta.-L-FTC; PSI-5004; CHEMBL885; DSSTox_CID_20129; DSSTox_RID_79445; DSSTox_GSID_40129; SCHEMBL39708; MLS003882429; MLS006011556; MLS006011987; DTXSID0040129; GTPL11244; EX-A150; HMS2089I05; HMS3713L12; ZINC3629271; Tox21_112193; ((-))-FTC; ABP001074; ANW-58684; BDBM50107843; BW1592; CE0036; FTC-((-)); NSC804863; AKOS015853098; AKOS015894950; AM84393; CCG-220615; CS-1370; DB00879; MCULE-7141046266; NE44626; NSC-804863; SB18984; 2',3'-Dideoxy-3-thia-5-fluorocytidine; NCGC00164564-06; NCGC00164564-10; AS-14099; HY-17427; CAS-143491-57-0; Emtricitabine 100 microg/mL in Acetonitrile; SW220172-1; C12599; D01199; ent-Emtricitabine; Emtricitabine IP Impurity D; 24229-EP2298783A1; 24229-EP2314590A1; AB01275429-01; 491E570; Q422604; 524-W-91; W-201247; W-201248; Z1739256297; UNII-ULS8902U4O component XQSPYNMVSIKCOC-NTSWFWBYSA-N; .beta.-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
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Clinical Status |
Approved
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Disease Indication | Viral hepatitis | ICD-11: 1E51 | [1] | ||
PubChem CID | |||||
Formula |
C8H10FN3O3S
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Canonical SMILES |
C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F
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InChI |
1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
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InChIKey |
XQSPYNMVSIKCOC-NTSWFWBYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=60877"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 247.25 | Topological Polar Surface Area | 113 | |
XlogP | -0.6 | Complexity | 374 | ||
Heavy Atom Count | 16 | Rotatable Bond Count | 2 | ||
Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 5 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Emtricitabine 200 mg capsule | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Water; Crospovidone; Povidone; Cellulose, microcrystalline; Gelatin
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Dosage Form | Oral Capsule | |||||
Company | Physicians Total Care | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 2 | DIG Info | Adenosine receptor A3 (IC50 = 1 uM) | [2] | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Water; Crospovidone; Cellulose, microcrystalline; Gelatin; Povidones
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Dosage Form | Oral Capsule | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 2 | DIG Info | Adenosine receptor A3 (IC50 = 1 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Water; Crospovidone (15 mpa.s at 5%); Gelatin, unspecified; Microcrystalline cellulose; Povidone, unspecified
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Dosage Form | Oral Capsule | |||||
Company | Gilead Sciences | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 2 | DIG Info | Adenosine receptor A3 (IC50 = 1 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
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