Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00265)
Name
Febuxostat
Synonyms    Click to Show/Hide the Synonyms of This API
Febuxostat; 144060-53-7; Adenuric; Uloric; 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid; Tei 6720; Tei-6720; Feburic; TMX 67; TMX-67; 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid; C16H16N2O3S; UNII-101V0R1N2E; Febuxostat (Uloric); 2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID; CHEMBL1164729; 101V0R1N2E; NCGC00182059-02; 5-Thiazolecarboxylic acid, 2-(3-cyano-4-(2-methylpropoxy)phenyl)-4-methyl-; DSSTox_CID_28576; DSSTox_RID_82848; DSSTox_GSID_48650; 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-; SMR002529566; Uloric (TN); CAS-144060-53-7; 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid; 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid; Donifoxate; Febuxostatum; Febuday; Goturic; Febric; Goutex; Febuxostat (JAN/USAN/INN); Febuxostat [USAN:INN:BAN]; Feburic (TN); Febuxostat(Uloric) /; SPIRAMYCINADIPATE; 111GE013; Febuxostat(TEI 6720); 2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic acid; Febuxostat,Uloric, TMX-67; cc-566; MLS004774136; MLS006011568; SCHEMBL249339; GTPL6817; ZINC5423; thyl-thiazole-5-carboxylic acid; DTXSID8048650; Febuxostat, >=98% (HPLC); CHEBI:31596; BCPP000233; HMS3264C20; HMS3655C03; HMS3673M21; HMS3743I09; HMS3868J03; Pharmakon1600-01504286; ACT06289; BCP02342; Tox21_113004; ABP000399; AC-425; ANW-46040; BBL036503; BDBM50320491; FD7322; MFCD00871598; NSC758874; STL559020; AKOS015841695; Tox21_113004_1; BCP9000679; BS-1018; CCG-213303; CS-0403; DB04854; MCULE-6974079178; NSC-758874; PB33929; 2-(3-Cyano-4-isobutoxy-phenyl)-4-me; NCGC00182059-03; AK-83533; HY-14268; AB0005158; AM20090760; FT-0601639; SW219283-1; D01206; J10392; Q-4339; AB01274796-01; AB01274796_02; AB01274796_03; 060F537; Q417296; SR-01000940023; Q-100164; SR-01000940023-2; BRD-K48367671-001-01-8; Z1550648761; 2-(3-cyano-4-isobutyloxy)-phenyl-4-methyl-5-thiazolecarboxylic acid; 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid
Clinical Status
Approved
Disease Indication Hyperuricaemia ICD-11: 5C55 [1]
PubChem CID
134018
Formula
C16H16N2O3S
Canonical SMILES
CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O
InChI
1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
InChIKey
BQSJTQLCZDPROO-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=134018"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 316.4 Topological Polar Surface Area 111
XlogP 3.9 Complexity 448
Heavy Atom Count 22 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Febuxostat 40 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Cardinal Health; Takeda Pharmaceuticals America
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h)
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Febuxostat 80 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Takeda Pharmaceuticals America
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved febuxostat from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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