Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00282) | |||||
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Name |
Fludrocortisone
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Synonyms |
Click to Show/Hide the Synonyms of This API
fludrocortisone; Fluorocortisone; Fluohydrisone; Fluorocortisol; Florinef; 127-31-1; Astonin-H; Fluohydrocortisone; Fludrocortone; 9alpha-Fluorocortisol; Alflorone; Fludrone; Fludronef; Fluodrocortisone; F-Cortef; 9-Fluorocortisol; Fludrocortisona; Fludrocortisonum; 9-Fluorohydrocortisone; Cortisol, 9-fluoro-; StC 1400; 9 .alpha. FF; 9.alpha.-Fluorocortisol; 9.alpha.-Fluorohydrocortisone; Corticosterone, 9-fluoro-17-hydroxy-; U 5963; NSC 11318; UNII-U0476M545B; 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9.alpha.-Fluoro-17-hydroxycorticosterone; 127-31-1 (free); CHEBI:50885; 9 alpha FF; (11beta)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; LMST02030103; U0476M545B; NCGC00181081-01; 9alpha-Fludrocortisone; 9-alpha-Fluorocortisol; 9alpha-fluoro-11beta,17alpha,21-trihydroxy-pregn-4-ene-3,20-dione; DSSTox_CID_3061; 9-alpha-Fludrocortisone; Fludrocortisonum [INN-Latin]; Fludrocortisona [INN-Spanish]; DSSTox_RID_76858; DSSTox_GSID_23061; Fludrocortisone [INN:BAN]; 9-alpha-Fluorohydrocortisone; 9alpha-Fluoro-hydrocortisone; Hydrocortisone-9alpha-fluoro; CAS-127-31-1; 9alpha-Fluoro-17-hydroxycorticosterone; 9-alpha-Fluoro-17-hydroxycorticosterone; Astonin-H (TN); C21H29FO5; HSDB 3332; Fludrocortisone (INN); EINECS 204-833-2; BRN 3014278; 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione; Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-; Prestwick_648; 9alpha-Flourocortisol; 9.alpha.-Fluorcortisol; Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-; bmse000987; bmse001009; SCHEMBL4545; 4-08-00-03427 (Beilstein Handbook Reference); GTPL2873; CHEMBL1201388; DTXSID7023061; 9-Fluoro-11.beta.,17,21-trihydroxypregn-4-ene-3,20-dione; HY-B1203; NSC11318; Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-; ZINC4097304; Tox21_112700; Tox21_113344; NSC-11318; 9.alpha.-Fluoro-11.beta.,17.alpha.,21-trihydroxy-4-pregnene-3,20-dione; Tox21_113344_1; A-Fludrocortisone;9; A-Fluorcortisol; CS-4832; DB00687; NCGC00274078-01; C07004; D07967; 20529-EP2314585A1; Q2697578; W-108386; Pregn-4-ene-3, 9-fluoro-11.beta.,17,21-trihydroxy-; WLN: L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ; 9-Fluoro-11.beta.,21-trihydroxypregn-4-ene-3,20-dione; (11.beta.)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; (11alpha)-9-fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; 9.alpha.-Fluoro-11.beta.,21-trihydroxy-4-pregnene-3,20-dione; Pregn-4-ene-3, 9-fluoro-11,17,21-trihydroxy-, (11.beta.)-; Pregn-4-ene-3,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-; Pregn-4-ene-3,20-dione,9-fluoro-11,17,21-trihydroxy-,(11; 9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione, (11.beta.)- #; Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy- (8CI)
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Clinical Status |
Approved
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Disease Indication | Hyponatraemia | ICD-11: 5C72 | [1] | ||
PubChem CID | |||||
Formula |
C21H29FO5
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Canonical SMILES |
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O)F
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InChI |
1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1
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InChIKey |
AAXVEMMRQDVLJB-BULBTXNYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=31378"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 380.4 | Topological Polar Surface Area | 94.8 | |
XlogP | 1.7 | Complexity | 734 | ||
Heavy Atom Count | 27 | Rotatable Bond Count | 2 | ||
Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 6 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Fludrocortisone 0.1 mg tablet | Click to Show/Hide the Full List of Formulation(s): 5 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Anhydrous dibasic calcium phosphate; Talc; Aluminum oxide; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Calcium phosphate, dibasic, dihydrate; Talc; Aluminum oxide; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | PD-Rx Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Dibasic calcium phosphate dihydrate; Talc; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Teva Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
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Dosage Form | Oral Tablet | |||||
Company | American Health Packaging; AvKARE; AvPAK; Cardinal Health; Impax Generics; NCS HealthCare of KY, Inc dba Vangard Labs; Physicians Total Care | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [3] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Talc; Corn starch 3-e-dodecenyl succinic anhydride modified
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Dosage Form | Oral Tablet | |||||
Company | West-Ward Pharmaceticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Fludrocortisone Acetate 0.1mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous Lactose; Starch, Corn; Dibasic Calcium Phosphate Dihydrate; D&C Yellow No. 10 Aluminum Lake; Magnesium Stearate; Sodium Starch Glycolate Type A Potato; Talc
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Dosage Form | Tablet | |||||
Company | Teva Pharmaceuticals Usa | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Croscarmellose Sodium; Lactose Monohydrate; Magnesium Stearate; Cellulose, Microcrystalline
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Dosage Form | Tablet | |||||
Company | Amneal Pharmaceuticals Ny | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [3] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Croscarmellose Sodium; Lactose Monohydrate; Magnesium Stearate; Microcrystalline Cellulose
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Dosage Form | Tablet | |||||
Company | Cardinal Health | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [3] | |||
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