Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00323) | |||||
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Name |
Iloperidone
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Synonyms |
Click to Show/Hide the Synonyms of This API
Iloperidone; 133454-47-4; Zomaril; Fanapt; Fanapta; HP 873; HP-873; Iloperidone (Fanapt); UNII-VPO7KJ050N; C24H27FN2O4; VPO7KJ050N; CHEMBL14376; CHEBI:65173; NCGC00188864-01; DSSTox_CID_28986; DSSTox_RID_83251; DSSTox_GSID_49060; Fiapta; SMR002529575; Fanapt (TN); CAS-133454-47-4; Iloperidone (USAN/INN); iloperidona; iloperidonum; Iloperidone [USAN:INN:BAN]; HSDB 8207; ILO-522; Zomaril; Fanapt; Iloperidone solution; Iloperidone(Fanapt)/; GTPL87; cc-306; MLS004774132; MLS006011943; SCHEMBL115755; DTXSID6049060; Iloperidone, >=98% (HPLC); AOB6366; BCPP000206; HMS3604B21; HMS3654J14; HMS3884A19; (non-Isotopelabelled)Iloperidone-d6; ACT02698; BCP02042; ZINC1548097; Tox21_113610; ABP000554; BDBM50034043; CI0025; MFCD00866688; PDSP1_000514; PDSP1_000515; PDSP2_000512; PDSP2_000513; AKOS005146266; Tox21_113610_1; AC-3482; BCP9000774; CCG-268962; CS-1236; DB04946; MCULE-1792333504; VA11078; NCGC00188864-02; NCGC00188864-10; HY-17410; AB0005018; AM20090764; FT-0631148; FT-0670284; SW219279-1; D02666; W-5150; AB01274793-01; AB01274793_02; 454I474; A806617; L001176; SR-01000940095; J-503185; Q4199443; SR-01000940095-2; Z1691545119; Iloperidone, United States Pharmacopeia (USP) Reference Standard
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Clinical Status |
Approved
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Disease Indication | Schizophrenia | ICD-11: 6A20 | [1] | ||
PubChem CID | |||||
Formula |
C24H27FN2O4
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Canonical SMILES |
CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
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InChI |
1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
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InChIKey |
XMXHEBAFVSFQEX-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=71360"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 426.5 | Topological Polar Surface Area | 64.8 | |
XlogP | 4.1 | Complexity | 586 | ||
Heavy Atom Count | 31 | Rotatable Bond Count | 8 | ||
Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 7 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Iloperidone 1 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sodium bicarbonate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Novartis Pharmaceuticals Corporation | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Vanda Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Iloperidone 10 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sodium bicarbonate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Novartis Pharmaceuticals Corporation | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Vanda Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Iloperidone 2 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sodium bicarbonate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Novartis Pharmaceuticals Corporation | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Vanda Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Iloperidone 4 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sodium bicarbonate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Avera McKennan Hospital; Novartis Pharmaceuticals Corporation | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Avera McKennan Hospital; Vanda Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Iloperidone 8 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sodium bicarbonate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Novartis Pharmaceuticals Corporation | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Vanda Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Iloperidone 12 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Novartis Pharmaceuticals Corporation | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Sodium bicarbonate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Vanda Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Iloperidone 6 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Novartis Pharmaceuticals Corporation | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
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Dosage Form | Oral Tablet | |||||
Company | Vanda Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium bicarbonate; Water; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Magnesium salicylate
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
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