Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00362)
Name
Levomilnacipran
Synonyms    Click to Show/Hide the Synonyms of This API
Levomilnacipran; Fetzima; UNII-UGM0326TXX; 96847-54-0; UGM0326TXX; CHEMBL99946; F 2695; (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide; F-2695; (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide; 96847-55-1; Levomilnacipran [USAN:INN]; Milnacipram; (+)-Milnacipran; (1S,2R)-milnacipran; Levomilnacipran (USAN/INN); ZINC506; GTPL7435; SCHEMBL1414867; CHEBI:136040; BDBM50032379; DB08918; SB17447; f2-695; D10072; Q6535779; UNII-G56VK1HF36 component GJJFMKBJSRMPLA-DZGCQCFKSA-N; (1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxylic acid diethylamide; Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, (1S,2R)-
Clinical Status
Approved
Disease Indication Major depressive disorder ICD-11: 6A70 [1]
PubChem CID
6917779
Formula
C15H22N2O
Canonical SMILES
CCN(CC)C(=O)[C@]1(C[C@H]1CN)C2=CC=CC=C2
InChI
1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1
InChIKey
GJJFMKBJSRMPLA-DZGCQCFKSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6917779"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 246.35 Topological Polar Surface Area 46.3
XlogP 1.4 Complexity 295
Heavy Atom Count 18 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Levomilnacipran 120 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Ferric oxide red; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Povidone; Ethylcelluloses; Hypromelloses; Shellac
                   Dosage Form 24 HR Extended Release Oral Capsule
                   Company Allergan
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
          Levomilnacipran 20 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Povidone; Ethylcelluloses; Hypromelloses; Shellac
                   Dosage Form 24 HR Extended Release Oral Capsule
                   Company Allergan
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
          Levomilnacipran 40 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Povidone; Ethylcelluloses; Hypromelloses; Shellac
                   Dosage Form 24 HR Extended Release Oral Capsule
                   Company Allergan; Avera McKennan Hospital
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
          Levomilnacipran 80 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Ferric oxide red; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Povidone; Ethylcelluloses; Hypromelloses; Shellac
                   Dosage Form 24 HR Extended Release Oral Capsule
                   Company Allergan
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
References
1 FDA label for approved levomilnacipran from the official website of the U.S. Food and Drug Administration.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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