Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00397) | |||||
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Name |
Meperidine
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Synonyms |
Click to Show/Hide the Synonyms of This API
meperidine; Pethidine; Demerol; Isonipecaine; Pethidin; Meperidol; Pethanol; Pethidineter; Phetidine; Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate; Pipersal; Nemerol; 57-42-1; Petydyna; Petidina; Pethidinum; 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester; Ethyl 1-methyl-4-phenylisonipecotate; Methyl phenylpiperidine carbonic acid ethyl ester; N-Methyl-4-phenyl-4-carbethoxypiperidine; Isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester; 1-Methyl-4-phenylisonipecotic acid, ethyl ester; 1-Methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester; HSDB 3116; UNII-9E338QE28F; 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester; CHEMBL607; Mepergan; 1-Methyl-4-phenyl-piperidin-4-carbon-saeure-aethylester; CHEBI:6754; IDS-NP-001; 9E338QE28F; meperidina; Mepridine; Petydyna [Polish]; Demarol; Piperosal; Pethidinum [INN-Latin]; Petidina [INN-Spanish]; 1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester; Pethidine (INN); Pethidine DBL (TN); Pethidine [INN:BAN]; EINECS 200-329-1; Renaudin; DEA No. 9230; 1-Methyl-4-phenyl-piperidin-4-carbon-saeure-aethylester [German]; Lidol (Salt/Mix); Lydol (Salt/Mix); Dolsin (Salt/Mix); Dolaren (Salt/Mix); Dolosal (Salt/Mix); Dispadol (Salt/Mix); Dolantin (Salt/Mix); Petantin (Salt/Mix); Operidine (Salt/Mix); Piridosal (Salt/Mix); 4-Carbethoxy-1-methyl-4-phenylpiperidine; Centralgin (Salt/Mix); Dolcontral (Salt/Mix); 1-methyl-4-phenylisonipecotic acid ethyl ester; Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate; SCHEMBL25431; DivK1c_000983; GTPL7221; ZINC1681; DTXSID9023253; KBio1_000983; NINDS_000983; YIsonipecotic acid, 1-methyl-4-phenyl-, ethyl ester (8CI); BDBM50026752; DB00454; IDI1_000983; DB-053051; C07128; D08343; Pethidine (Meperidine) 0.1 mg/ml in Methanol; Pethidine (Meperidine) 1.0 mg/ml in Methanol; Q55434; 4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium; L000908; SR-01000944492; SR-01000944492-1; Meperidine solution, 1 mg/mL in methanol, drug standard; 1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester(Meperidine); Meperidine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
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Clinical Status |
Approved
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Disease Indication | Anaesthesia | ICD-11: 8E22 | [1] | ||
PubChem CID | |||||
Formula |
C15H21NO2
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Canonical SMILES |
CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2
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InChI |
1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3
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InChIKey |
XADCESSVHJOZHK-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4058"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 247.33 | Topological Polar Surface Area | 29.5 | |
XlogP | 2.5 | Complexity | 276 | ||
Heavy Atom Count | 18 | Rotatable Bond Count | 4 | ||
Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 3 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Meperidine 150 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 27; Fd&c yellow no. 6; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Mikart | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
D&C red no. 27 | DIG Info | Solute carrier SLCO2B1 (Ki = 1 uM) | [3] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [3] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Meperidine 100 mg tablet | Click to Show/Hide the Full List of Formulation(s): 9 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Talc; Povidone; Dibasic calcium phophate; Microcrystalline cellulose; Pregelatinized starch
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Dosage Form | Oral Tablet | |||||
Company | Mallinckrodt | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [5] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous dibasic calcium phosphate; Calcium sulfate; Talc; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Physicians Total Care | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous dibasic calcium phosphate; Calcium sulfate; Talc; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Sanofi-Aventis | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Epic Pharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Mikart | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 6 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium sulfate; Talc; Calcium phosphate, dibasic, anhydrous; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Validus Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Drug Formulation 7 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Qualitest Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Drug Formulation 8 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Povidone k30; Microcrystalline cellulose; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | West-Ward Pharmaceticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [4] | |||
Drug Formulation 9 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
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Dosage Form | Oral Tablet | |||||
Company | Barr Laboratories; Caraco Pharmaceutical Laboratories; Teva Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [4] | |||
Meperidine 50 mg tablet | Click to Show/Hide the Full List of Formulation(s): 11 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Talc; Povidone; Dibasic calcium phophate; Microcrystalline cellulose; Pregelatinized starch
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Dosage Form | Oral Tablet | |||||
Company | Mallinckrodt | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [5] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous dibasic calcium phosphate; Calcium sulfate; Talc; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Physicians Total Care | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous dibasic calcium phosphate; Calcium sulfate; Talc; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Sanofi-Aventis | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Epic Pharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Mikart | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Drug Formulation 6 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium sulfate; Talc; Calcium phosphate, dibasic, anhydrous; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Validus Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Drug Formulation 7 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium sulfate; Talc; Calcium phosphate, dibasic, anhydrous; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Bryant Ranch Prepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Drug Formulation 8 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Physicians Total Care; Qualitest Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Drug Formulation 9 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Microcrystalline cellulose; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Bryant Ranch Prepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Drug Formulation 10 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Povidone k30; Microcrystalline cellulose; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | West-Ward Pharmaceticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [4] | |||
Drug Formulation 11 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
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Dosage Form | Oral Tablet | |||||
Company | Barr Laboratories; Caraco Pharmaceutical Laboratories; Teva Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [4] | |||
Meperidine 75 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Mikart | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [3] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
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