Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00400)
Name
Sibutramine
Synonyms    Click to Show/Hide the Synonyms of This API
Sibutraminum [Latin]; Sibutramina [Spanish]; 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine; 1-(1-(4-chlorophenyl)cyclobutyl)-N,N,3-trimethylbutan-1-amine; CHEBI:9137; Sibutramina; Sibutraminum; Sibutramine [INN:BAN]; Butramin (TN); SMR000238156; Sibutramine (INN); (R)-DDMS; Sibutramine-d6; DEA No. 1675; BTS 54 524; Spectrum_001961; Spectrum2_001686; Spectrum3_001009; Spectrum4_001137; Spectrum5_001440; SCHEMBL2955; CHEMBL1419; BSPBio_002737; KBioGR_001653; KBioSS_002516; MLS001066619; MLS001401362; SPBio_001612; CYC087; GTPL2586; DTXSID1023578; BDBM84742; HSDB 7209; KBio2_002508; KBio2_005076; KBio2_007644; KBio3_001957; HMS2052P05; HMS2090N17; HMS2272C06; HMS3394P05; 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-1-butanamine; BCP08127; NSC_5210; ANW-68883; BBL010956; STK802066; AKOS004119970; AKOS022060500; CCG-101166; DB01105; MCULE-6656338642; NC00416; Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)-; NCGC00092357-02; NCGC00092357-04; ( inverted exclamation markA)-Sibutramine; AC-15773; SBI-0206737.P001; CAS_106650-56-0; FT-0674580; 50S560; C07247; D08513; AB00949538-11; AB00949538_12; Q424151; {1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}dimethylamine; (.+/-.)-1-(p-Chlorophenyl)-.alpha.-isobutyl-N,N-dimethylcyclobutanemethylamine; Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-; A-(2-methylpropyl)-
Clinical Status
Approved
Disease Indication Obesity ICD-11: 5B81 [1]
PubChem CID
5210
Formula
C17H26ClN
Canonical SMILES
CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N(C)C
InChI
1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3
InChIKey
UNAANXDKBXWMLN-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5210"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 279.8 Topological Polar Surface Area 3.2
XlogP 5.4 Complexity 275
Heavy Atom Count 19 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Sibutramine 5 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Gelatin
                   Dosage Form Oral Capsule
                   Company Abbott
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Sibutramine 10 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Gelatin
                   Dosage Form Oral Capsule
                   Company Abbott
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Sibutramine 15 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Gelatin
                   Dosage Form Oral Capsule
                   Company Abbott
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved sibutramine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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