Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00402)
Name	Mesna
Synonyms	Click to Show/Hide the Synonyms of This API 19767-45-4; Sodium 2-mercaptoethanesulfonate; Mesnex; Uromitexan; Mistabron; 2-Mercaptoethanesulfonic acid sodium salt; Mistabronco; Mucofluid; Sodium 2-mercaptoethane sulfonate; Ethanesulfonic acid, 2-mercapto-, monosodium salt; UNII-NR7O1405Q9; Mitexan; 2-mercaptoethanesulfonic acid sodium; Sodium 2-mercaptoethanesulfonate;Mesnum; sodium;2-sulfanylethanesulfonate; Mesnum; NR7O1405Q9; MFCD00007535; Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1); NCGC00181166-01; DSSTox_CID_809; D 7093; D-7093; DSSTox_RID_75800; DSSTox_GSID_20809; Mesnum [INN-Latin]; C2H5NaO3S2; SMR000059219; CAS-19767-45-4; Natrium 2-mercaptoethansulfonat; CCRIS 3712; 2-Mercaptoethane sulfonate sodium; NSC-113891; EINECS 243-285-9; NSC 113891; 2-Mercaptoethanesulfonic acid sodium salt, 98%, analytical standard; 2-Mercapto-ethan-sulfonsaeure, natrium-salz; 2-Mercaptoethanesulfonic acid monosodium salt; Mesna [USAN:USP:INN:BAN]; 2-Mercaptoethanesulfonate, sodium; Uromitexan (TN); sodium 2-mercaptoethane-1-sulfonate; sodium 2-sulfanylethane-1-sulfonate; Mesnex (TN); Prestwick_1005; Spectrum2_000752; Spectrum3_001483; Spectrum4_000041; Spectrum5_001174; Mesna (JAN/USP/INN); ACMC-209f1l; CHEMBL975; SCHEMBL7993; Mesna (Uromitexan, Mesnex); KBioGR_000501; MLS001074691; MLS001333251; MLS001333252; SPECTRUM1502014; SPBio_000764; DTXSID1020809; CHEBI:31824; HMS502F17; KBio3_002565; EBD6310; HMS1921D10; HMS2092N09; HMS2236L05; HMS3259D13; HMS3372M11; HMS3655M06; HMS3715H05; sodium, 2-mercapto-ethanesulfonate; BCP14384; Tox21_112767; Tox21_200863; ANW-23767; BDBM50247978; CCG-40134; AKOS006220661; AKOS015960755; Tox21_112767_1; AC-6011; CS-1364; NC00648; NCGC00094939-01; NCGC00094939-02; NCGC00178318-04; NCGC00258417-01; 2-mercaptoethanesulphonic acid sodium salt; AK163673; AS-13260; HY-13679; AB0013231; DB-044962; SW199618-2; EN300-49858; D01459; M-2956; AB01274734-01; Q424997; Sodium 2-mercaptoethanesulfonate; Mesnaum; Mesnex; W-60283; Q-201713; 3-AMINOOXY-N-PROPYL(DIMETHYL-T-BUTYLSILYL)ETHER; Z1741968275
Clinical Status	Approved
Disease Indication	Infectious cystitis		ICD-11: GC00	[1]
PubChem CID	23662354
Formula	C2H5NaO3S2
Canonical SMILES	C(CS(=O)(=O)[O-])S.[Na+]
InChI	1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
InChIKey	XOGTZOOQQBDUSI-UHFFFAOYSA-M
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=23662354"></iframe>
Structure	3D MOL is unavailable		2D MOL
Physicochemical Properties	Molecular Weight	164.18	Topological Polar Surface Area	66.6
	XlogP	N.A.	Complexity	123
	Heavy Atom Count	8	Rotatable Bond Count	2
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	4

Full List of Drug Formulations (DFMs) Containing This API
Mesna 400 mg tablet			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose; Magnesium stearate; Calcium phosphate, dibasic, dihydrate; Titanium dioxide; Cellulose, microcrystalline; Dimethicone; Hydroxypropyl cellulose (type h); Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Bayer HealthCare
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[2]

References
1	FDA label for approved mesna from the official website of the U.S. Food and Drug Administration.
2	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.