Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00403)
Name
Metaproterenol
Synonyms    Click to Show/Hide the Synonyms of This API
metaproterenol; ORCIPRENALINE; 586-06-1; Alupent; Orciprenalinum; Orciprenalinum [INN-Latin]; Orciprenalina [INN-Spanish]; Prometa; Orciprenaline [INN]; 5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol; Orciprenaline (INN); CHEMBL776; CHEBI:6792; 5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol; Orciprenalina; CCRIS 9017; TH-152; SR-01000075168; EINECS 209-569-1; Orciprenaline [INN:BAN]; BRN 2807247; Orciprenalin; (RS)-1-(3,5-Dihydroxyphenyl)-2-isopropylaminoethanol; 3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol; Spectrum_000925; ACMC-20m2sn; Prestwick0_000505; Prestwick1_000505; Prestwick2_000505; Prestwick3_000505; Spectrum2_000096; Spectrum3_000492; Spectrum4_000044; Spectrum5_000952; SCHEMBL4270; Lopac0_000734; BSPBio_000429; BSPBio_001983; KBioGR_000507; KBioSS_001405; DivK1c_000645; SPECTRUM1500390; SPBio_000052; SPBio_002350; BPBio1_000473; GTPL7250; DTXSID8048529; CHEBI:83329; HMS502A07; HY-B1276A; KBio1_000645; KBio2_001405; KBio2_003973; KBio2_006541; KBio3_001483; NINDS_000645; HMS1920L09; HMS2091D04; HMS3259J13; Pharmakon1600-01500390; 1,3-Benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-; Benzyl alcohol, 3,5-dihydroxy-alpha-((isopropylamino)methyl)-; BDBM50295572; CCG-38914; NSC757089; DB00816; MCULE-8722254342; NC00651; NSC-757089; SDCCGSBI-0050712.P005; IDI1_000645; NCGC00015655-02; NCGC00015655-03; NCGC00015655-04; NCGC00015655-05; NCGC00015655-06; NCGC00015655-14; NCGC00094718-01; NCGC00094718-02; NCGC00094718-03; SBI-0050712.P004; AB00052037; CS-0013668; C07144; D08300; 1-(3,5-Dihydroxyphenyl)-2-isopropylaminoethanol; AB00052037_09; AB00052037_10; 586O061; L000678; Q416473; SR-01000075168-1; SR-01000075168-4; BRD-A07780951-001-06-3; 5-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,3-diol; 5-(1-Hydroxy-2-isopropylamino-ethyl)-benzene-1,3-diol; 3,5-dihydroxy-alpha-[(isopropylamino)methyl]benzenemethanol; 5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol; 5-[1-Hydroxy-2-(isopropylamino)ethyl]-1,3-benzenediol #; [2-(3,5-Dihydroxy-phenyl)-2-hydroxy-ethyl]-isopropyl-ammonium; 3,5-Dihydroxy-.alpha.-((isopropylamino)methyl)benzyl alcohol; 5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol, 6; Benzyl alcohol, 3,5-dihydroxy-.alpha.-((isopropylamino)methyl)-; 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)- (9CI); 1,3-Benzenediol, 5-[(1R)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]-; [2-(3,5-Dihydroxy-phenyl)-2-hydroxy-ethyl]-isopropyl-ammonium (orciprenaline); 99396-41-5
Clinical Status
Approved
Disease Indication Asthma ICD-11: CA23 [1]
PubChem CID
4086
Formula
C11H17NO3
Canonical SMILES
CC(C)NCC(C1=CC(=CC(=C1)O)O)O
InChI
1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3
InChIKey
LMOINURANNBYCM-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4086"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 211.26 Topological Polar Surface Area 72.7
XlogP 0.7 Complexity 177
Heavy Atom Count 15 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Metaproterenol 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Metaproterenol 20 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved metaproterenol from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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