Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00410)
Name
Methimazole
Synonyms    Click to Show/Hide the Synonyms of This API
methimazole; 60-56-0; thiamazole; Tapazole; 2-Mercapto-1-methylimidazole; Methimazol; 1-Methylimidazole-2-thiol; Mercazole; Mercazolyl; Metazolo; Thymidazol; Thymidazole; Mercaptazole; Merkazolil; Metothyrin; Metothyrine; Strumazol; Thiamazol; Thycapzol; Basolan; Favistan; 1-Methyl-1H-imidazole-2-thiol; Danantizol; Frentirox; Merkastan; Metotirin; Thacapzol; Thycapsol; Metizol; Mercasolyl; Methylmercaptoimidazole; 1-Methyl-2-mercaptoimidazole; 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-; Methiamazole; Usaf el-30; 3-methyl-1H-imidazole-2-thione; N-Methyl-2-mercaptoimidazole; Tapuzole; Thimazole; 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE; 1-Methyl-2-imidazolethiol; 1-Methyl-1H-imidazole-2(3H)-thione; 2-Mercaptomethylimidazole; 1,3-Dihydro-1-methyl-2H-imidazole-2-thione; 1-Methylimidazole-2(3H)-thione; Imidazole-2-thiol, 1-methyl-; 1-Metylo 2 merkaptoimidazolem; 1-Methyl-1,3-dihydroimidazole-2-thione; 4-Imidazoline-2-thione, 1-methyl-; MFCD00179321; Methimazole (USP); Methimazole [USP]; UNII-554Z48XN5E; Tiamazol; CHEMBL1515; Mercazolylum; Methimazolum; Metimazol; CHEBI:50673; Imidazole, 1-methyl-2-mercapto-; 554Z48XN5E; NSC38608; NSC-38608; CAS-60-56-0; Tiamazolo [DCIT]; NCGC00016273-01; Methamazole; Thiamazolum; Strumazole; Tiamazolo; DSSTox_CID_820; Thiamazol [INN-French]; Tiamazol [INN-Spanish]; DSSTox_RID_75808; DSSTox_GSID_20820; Thiamazolum [INN-Latin]; Felimazole; 2-Mercapto-1-methylimidazole, 98%; Tapazole (TN); 223768-14-7; SMR000058376; 1-Metylo 2 merkaptoimidazolem [Polish]; HSDB 3361; SR-05000001672; EINECS 200-482-4; NSC 38608; 1-Methyl-imidazole-2-thiol; tiamazole; AI3-60285; Methimazole-d3; 1,3-Dihydro-1-Methyl-2H-Imidazol-2-Thione; Thiamazole,(S); 2-Mercapto-1-methyl-1H-imidazole; Thiamazole [INN]; Prestwick_1010; Spectrum_000995; Prestwick0_000786; Prestwick1_000786; Prestwick2_000786; Prestwick3_000786; Spectrum2_001273; Spectrum3_000495; Spectrum4_000048; Spectrum5_000954; ACMC-1CF3S; Thiamazole (JP17/INN); 1-methylimidazole-2-thione; Methimazole-d3(methyl-d3); N-methyl imidazole-2-thiol; 2-mecapto 1-methylimidazole; 2-Mercapto-1-methylimidazol; 2-mercapto-N-methylimidazole; SCHEMBL41647; 2-mercapto-3-methylimidazole; BSPBio_000892; BSPBio_001989; KBioGR_000515; KBioSS_001475; MLS000028413; MLS002548853; BIDD:GT0163; DivK1c_000188; SPECTRUM1500396; WLN: T5N CNJ A BSH; 1-methyl-2-mercapto-imidazole; 2-mercapto-1-methyl-imidazole; SPBio_001266; SPBio_002831; 1-Methyl-2-mercapto imidazole; Imidazole-2-thio, 1-methyl-; Methimazole(Tapazole,Northyx)/; BPBio1_000982; GTPL6649; Methimazole, analytical standard; DTXSID4020820; Methimazole (Tapazole, Northyx); 1-methyl-1H-immidazole-2-thiol; 1-methyl-3H-imidazole-2-thione; HMS500J10; KBio1_000188; KBio2_001475; KBio2_004043; KBio2_006611; KBio3_001489; 1-methyl-1-H-imidazole-2-thiol; NINDS_000188; HMS1570M14; HMS1920L17; HMS2090B17; HMS2091D12; HMS2094C05; HMS2097M14; HMS3259L09; HMS3651I13; HMS3714M14; Pharmakon1600-01500396; 1-Methyl-1H-imidazole-2-thiol #; BCP02147; HY-B0208; STR03572; ZINC1187543; Tox21_110341; Tox21_201341; Tox21_300532; ABP000635; AC-785; ANW-33524; BBL009603; BBL018698; BDBM50241361; CCG-39656; HTS001687; NSC757111; SBB041060; STK300018; STK802184; AKOS000119427; AKOS000269708; Tox21_110341_1; BS-3743; CCG-220786; DB00763; MCULE-9902292741; NC00636; NSC-757111; 2-Mercapto-1-methylimidazole, >=99%; IDI1_000188; NCGC00016273-02; NCGC00016273-03; NCGC00094721-01; NCGC00094721-02; NCGC00094721-03; NCGC00094721-04; NCGC00094721-05; NCGC00094721-06; NCGC00094721-07; NCGC00178875-01; NCGC00254307-01; NCGC00258893-01; SBI-0206922.P001; SBI-0206922.P004; AB0057793; DB-053649; Methimazole; 2-mercapto-1-methylimidazole; 2H-Imidazole-2-thione,3-dihydro-1-methyl-; FT-0603253; ST45029020; SW197088-3; 1-methyl-2,3-dihydro-1H-imidazole-2-thione; C07190; D00401; AB00443630-03; AB00443630-04; AB00443630_06; AB00443630_07; Methimazole, VETRANAL(TM), analytical standard; A832780; Q419663; SR-01000695434; Q-201364; SR-01000695434-2; SR-05000001672-1; SR-05000001672-2; BRD-K54416256-001-15-7; Z57901905; F0001-2396; F1679-0258; Thiamazole, European Pharmacopoeia (EP) Reference Standard; Methimazole, United States Pharmacopeia (USP) Reference Standard; 85916-84-3
Clinical Status
Approved
Disease Indication Thyrotoxicosis ICD-11: 5A02 [1]
PubChem CID
1349907
Formula
C4H6N2S
Canonical SMILES
CN1C=CNC1=S
InChI
1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChIKey
PMRYVIKBURPHAH-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=1349907"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 114.17 Topological Polar Surface Area 47.4
XlogP -0.3 Complexity 119
Heavy Atom Count 7 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Methimazole 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Eon Labs; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Talc; Colloidal silicon dioxide; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Dispensing Solution; Golden State Medical Supply; Heritage Pharmaceuticals; Par Pharmaceutical; Pfizer Laboratories; Rebel Distributors; RemedyRepack; Rising Pharmaceuticals; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Starch, potato
                   Dosage Form Oral Tablet
                   Company ECI Pharmaceuticals; Exact-Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Boca Pharmacal; Preferred Pharamaceuticals; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Methimazole 5 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Eon Labs; NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Golden State Medical Supply; Heritage Pharmaceuticals; Par Pharmaceutical; Pfizer Laboratories; Physicians Total Care; Preferred Pharamaceuticals; Rebel Distributors; RemedyRepack; Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Starch, potato
                   Dosage Form Oral Tablet
                   Company ECI Pharmaceuticals; Exact-Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Boca Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved methimazole from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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