Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00427)
Name
Metyrosine
Synonyms    Click to Show/Hide the Synonyms of This API
METYROSINE; 672-87-7; alpha-Methyl-L-tyrosine; Metirosine; Demser; (S)-alpha-Methyltyrosine; (S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; Methyltyrosine; alpha-Methyltyrosine; L-alpha-Methyl-p-tyrosine; Metirosinum; Metirosina; L-alpha-Methyltyrosine; Alpha-Methyl-L-P-Tyrosine; (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; (-)-alpha-Methyl-L-tyrosine; UNII-DOQ0J0TPF7; MK-781; alpha-Methyl-para-tyrosine; DOQ0J0TPF7; ALPHA-METHYL-L-TYR; CHEBI:6912; MFCD00064201; NCGC00094144-03; DSSTox_CID_3315; DSSTox_RID_76972; DSSTox_GSID_23315; L-588357-0; alpha-MPT; CAS-672-87-7; (R)-alpha-Methyltyrosine; alpha-methyl-paratyrosine; Metyrosine [USAN:USP]; Metirosinum [INN-Latin]; MK 781; Metirosina [INN-Spanish]; L-2-ME-TYR-OH; alpha-Me-Tyr-OH; Metirosine [INN]; Metyrosine (USP); EINECS 211-599-5; Demser (TN); a-methyl-L-p-tyrosine; L- -methyl-Tyrosine; L-AMPT; Metirosine (JAN/INN); Spectrum3_001846; H-(ME)TYR-OH; A-METHYL-L-TYROSINE; (S)-2-(4-Hydroxybenzyl)-2-aminopropanoic Acid; Lopac0_000811; SCHEMBL50398; BSPBio_003232; ZINC693; SPECTRUM2300312; GTPL6956; L 588357-0; CHEMBL1200862; DTXSID6023315; KBio3_002732; (-)-(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure; HMS3262D03; L-Tyrosine, alpha-methyl-, (-)-; Tox21_111253; Tox21_500811; AKOS016844271; Tox21_111253_1; AB02561; AM83582; CCG-204895; CS-W015723; DB00765; HY-W015007; LP00811; MCULE-5340647798; SDCCGSBI-0050788.P002; NCGC00015701-06; NCGC00094144-01; NCGC00094144-04; NCGC00094144-05; NCGC00094144-06; NCGC00094144-07; NCGC00094144-11; NCGC00261496-01; AC-32982; alpha-Methyl-L-tyrosine, >=98% (TLC); AS-47139; L-2-Methyl-3-(4-hydroxy-phenyl)alanine; EU-0100811; C07921; D00762; L-2-METHYL-3-(4-HYDROXYPHENYL)ALANINE; M 8131; 672M877; A835693; Q6824116; Z1617901128; UNII-X88TTO174Z component NHTGHBARYWONDQ-JTQLQIEISA-N; (2S)-2-azanyl-3-(4-hydroxyphenyl)-2-methyl-propanoic acid; Metyrosine, United States Pharmacopeia (USP) Reference Standard; (S)-a-Methyl-4-hydroxy phenylalanine, (S)-a-Methyltyrosine (>98%, >98%ee)
Clinical Status
Approved
Disease Indication Pheochromocytoma ICD-11: 5A75 [1]
PubChem CID
441350
Formula
C10H13NO3
Canonical SMILES
C[C@](CC1=CC=C(C=C1)O)(C(=O)O)N
InChI
1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChIKey
NHTGHBARYWONDQ-JTQLQIEISA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=441350"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 195.21 Topological Polar Surface Area 83.6
XlogP -1.6 Complexity 211
Heavy Atom Count 14 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Metyrosine 250 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Silicon dioxide; Gelatin; Hydroxypropyl cellulose (type h)
                   Dosage Form Oral Capsule
                   Company Aton Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved metyrosine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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