Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00438)
Name
Minoxidil
Synonyms    Click to Show/Hide the Synonyms of This API
minoxidil; 38304-91-5; Rogaine; Loniten; Regaine; Minoximen; Theroxidil; Lonolox; U-10858; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide; C9H15N5O; 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine; CHEBI:6942; 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide; Tricoxidil; 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine; Alopexil; Alostil; MFCD00063409; Minodyl; MLS000028566; Normoxidil; CHEMBL1372483; 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide; Minossidile [Italian]; Minoxidilum [INN-Latin]; NCGC00015673-08; Minoxidilum; SMR000058963; CAS-38304-91-5; Apo-Gain; DSSTox_CID_20685; DSSTox_RID_79541; 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide; DSSTox_GSID_40685; 2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate; Neoxidil; Avacor and Mintop; 2,6-diamino-4-piperidylpyrimidin-1-ol; SMR000326812; Loniten (TN); Rogaine (TN); Riup (TN); 2,4-Diamino-6-piperidinopyrimidine 3-oxide; SR-01000075331; SR-05000001479; 3-oxido-6-piperidin-1-ylpyrimidin-3-ium-2,4-diamine; U-10,858; Kopdil; Regaine For Men; Minoxidil,(S); Regaine For Women; UNII-5965120SH1; Prestwick_521; 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine; TM-160; Men''''s Rogaine; Women''''s rogaine; 6-amino-2-imino-4-(piperidin-1-yl)pyrimidin-1(2H)-ol; Rogaine Extra Strength; pyrimidin-1(2H)-ol; Spectrum_000969; Tocris-0583; Minoxidil Extra Strength; regid855572; Opera_ID_1150; Prestwick0_000020; Prestwick1_000020; Prestwick2_000020; Prestwick3_000020; Spectrum2_001053; Spectrum3_000509; Spectrum4_000063; Spectrum5_001299; Lopac-M-4145; CHEMBL802; M 4145; Minoxidil (JAN/USP/INN); CBiol_001798; Lopac0_000786; SCHEMBL29698; BSPBio_000059; BSPBio_001385; BSPBio_002037; KBioGR_000105; KBioGR_000585; KBioSS_000105; KBioSS_001449; MLS000859953; MLS001077294; DivK1c_000160; SCHEMBL232565; SPECTRUM1500415; SPBio_001006; SPBio_001980; BPBio1_000065; CHEMBL609587; GTPL4254; Minoxidil, >=99% (TLC); SGCUT00112; ZINC1735; DTXSID9040685; BCBcMAP01_000193; BDBM81463; CHEBI:92128; HMS500H22; KBio1_000160; KBio2_000105; KBio2_001449; KBio2_002673; KBio2_004017; KBio2_005241; KBio2_006585; KBio3_000209; KBio3_000210; KBio3_001537; NINDS_000160; BCPP000162; Bio1_000084; Bio1_000573; Bio1_001062; Bio2_000105; Bio2_000585; HMS1361F07; HMS1568C21; HMS1791F07; HMS1920P03; HMS1989F07; HMS2089L08; HMS2091F20; HMS2095C21; HMS2233E04; HMS2235N21; HMS3259P21; HMS3262M14; HMS3266O06; HMS3371E15; HMS3372M19; HMS3402F07; HMS3411G16; HMS3675G16; HMS3712C21; Pharmakon1600-01500415; ACT04612; BCP01409; CAS_4201; HY-B0112; NSC_4201; to_000070; ZINC6507066; Tox21_110193; Tox21_500786; 3853AH; BDBM50237593; CCG-40112; NSC757106; SBB056986; STL453211; AKOS015920078; AKOS016339636; Tox21_110193_1; 6-amino-2-imino-4-(piperidin-1-yl); AC-5271; BCP9000929; CCG-220020; CS-1867; DB00350; GS-3605; KS-5164; LP00786; NC00686; NSC-757106; SDCCGSBI-0050764.P005; IDI1_000160; IDI1_033855; SMP1_000192; NCGC00015673-01; NCGC00015673-02; NCGC00015673-03; NCGC00015673-04; NCGC00015673-05; NCGC00015673-06; NCGC00015673-07; NCGC00015673-09; NCGC00015673-10; NCGC00015673-11; NCGC00015673-13; NCGC00015673-20; NCGC00018278-01; NCGC00018278-02; NCGC00018278-03; NCGC00018278-04; NCGC00024666-01; NCGC00024666-02; NCGC00024666-03; NCGC00024666-04; NCGC00024666-05; NCGC00024666-06; NCGC00024666-07; NCGC00024666-08; NCGC00179672-01; NCGC00261471-01; BR-49175; SBI-0050764.P004; AB0013244; AB0093459; 2,6-Diamino-4-piperidinopyrimidine 1-Oxide; 5965120SH1; AB00513797; EU-0100786; FT-0620793; ST50993884; D00418; J10235; M-7481; U10858; 6-(1-Piperidinyl)-2,4-pyrimidinediamine3-oxide; AB00052047-08; AB00052047_09; AB00052047_10; AB00513797-02; NC1=CC(=N/C(/N1O)=N/[H])N1CCCCC1; 102666-EP2272841A1; 102666-EP2281816A1; 102666-EP2301936A1; 304M915; A824098; Q424165; 2,4-diamino-6-(1-piperidinyl)-pyrimidine-3-oxide; Q-201408; SR-01000075331-1; SR-01000075331-3; SR-01000075331-5; SR-05000001479-1; SR-05000001479-2; 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine; BRD-K06902185-001-05-2; BRD-K06902185-001-10-2; BRD-K14888893-001-02-3; Minoxidil, British Pharmacopoeia (BP) Reference Standard; Z1541638524; Minoxidil, European Pharmacopoeia (EP) Reference Standard; 2-azanylidene-3-oxidanyl-6-piperidin-1-yl-pyrimidin-4-amine; 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidino-pyrimidine; Minoxidil, United States Pharmacopeia (USP) Reference Standard; 6-amino-2-imino-4-(piperidin-1-yl)-1,2-dihydropyrimidin-1-ol; Minoxidil for system suitability, European Pharmacopoeia (EP) Reference Standard
Clinical Status
Approved
Disease Indication Essential hypertension ICD-11: BA00 [1]
PubChem CID
4201
Formula
C9H15N5O
Canonical SMILES
C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
InChI
1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChIKey
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4201"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 209.25 Topological Polar Surface Area 88.9
XlogP 1.2 Complexity 329
Heavy Atom Count 15 Rotatable Bond Count 1
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Minoxidil 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Actavis Pharma; Carilion Materials Management; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [2]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; American Health Packaging; Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Minoxidil 2.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Actavis Pharma; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [2]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Cardinal Health; Par Pharmaceutical; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved minoxidil from the official website of the U.S. Food and Drug Administration.
2 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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