Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00446)
Name
Moricizine
Synonyms    Click to Show/Hide the Synonyms of This API
MORICIZINE; Moracizine; 31883-05-3; Ethmozine; Moracizina; Moracizinum; Moracizinum [INN-Latin]; Moracizina [INN-Spanish]; Moricizine [USAN]; EN-313; Ethmozin; Etmozin; UNII-2GT1D0TMX1; Moracizine (INN); Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate; Moricizine (USAN); C22H25N3O4S; Ethyl (10-(3-morpholinopropanoyl)-10H-phenothiazin-2-yl)carbamate; ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate; 2GT1D0TMX1; CHEBI:6997; EN 313; Moracizine [INN]; ethyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate; ethyl {10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; [10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester; NCGC00016809-01; NCGC00016809-07; EINECS 250-854-5; Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester; Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester; Ethyl (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)carbamate; Prestwick0_001051; Prestwick1_001051; Prestwick2_001051; Prestwick3_001051; ethyl N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; TimTec1_000772; CHEMBL1075; EN-313 FREE BASE; Oprea1_682904; Oprea1_701257; SCHEMBL16794; BSPBio_001002; CBDivE_008814; MLS001201823; BIDD:GT0499; SPBio_002931; BPBio1_001104; GTPL7244; DTXSID4023335; HMS1536D02; HMS2852B19; BCP14374; HY-B0615; STK370502; ZINC19340795; AKOS001487682; ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate; DB00680; MCULE-2907779244; NCGC00016809-02; NCGC00016809-03; NCGC00016809-04; NCGC00074074-03; SMR000059585; ST012322; CAS-31883-05-3; DB-048124; AB00514710; FT-0630560; C07743; D05077; AB00514710-13; 883M053; Q904071; BRD-K21548250-003-03-5; ethyl 10-(3-morpholinopropanoyl)-10H-phenothiazin-2-ylcarbamate; [10-[3-(4-morpholinyl)-1-oxopropyl]-10h-phenothiazin-2-yl]-, ethyl ester; ethoxy-N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carboxamide; [10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl este; N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}ethoxycarboximidic acid; CARBAMICACID,[10-[3-(4-MORPHOLINYL)-1-OXOPROPYL]-10H-PHENOTHIAZIN-2-YL]-,ETHYLESTER
Clinical Status
Approved
Disease Indication Cardiac arrhythmia ICD-11: BC65 [1]
PubChem CID
34633
Formula
C22H25N3O4S
Canonical SMILES
CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4
InChI
1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27)
InChIKey
FUBVWMNBEHXPSU-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=34633"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 427.5 Topological Polar Surface Area 96.4
XlogP 3 Complexity 601
Heavy Atom Count 30 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Moricizine 200 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Dyes; Microcrystalline cellulose; Sodium starch glycolate
                   Dosage Form Oral Tablet
                   Company Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Moricizine 250 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Dyes; Microcrystalline cellulose; Sodium starch glycolate
                   Dosage Form Oral Tablet
                   Company Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Moricizine 300 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Dyes; Microcrystalline cellulose; Sodium starch glycolate
                   Dosage Form Oral Tablet
                   Company Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 Moricizine. A review of its pharmacological properties, and therapeutic efficacy in cardiac arrhythmias. Drugs. 1990 Jul;40(1):138-67.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.