Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00462)
Name
Neomycin
Synonyms    Click to Show/Hide the Synonyms of This API
neomycin; Framycetin; NEOMYCIN B; Mycifradin; Soframycin; Actiline; Fradiomycin; Neomas; Fradiomycinum; Framicetina; Framycetine; Framycetinum; Caswell No. 595; Neomycin B sulfate; Fradiomycin B; 119-04-0; NEOMYCIN SULFATE; USAF CB-19; 1404-04-2; CCRIS 5462; HSDB 3242; Soframycine; UNII-4BOC774388; Neo-Rx; Antibiotique; Enterfram; Nivemycin; Actilin; Framygen; Myacyne; Neolate; CHEBI:7508; Vonamycin powder V; Neomcin; Neomycin solution; Neomin; 4BOC774388; Neomicina [DCIT]; Framycetinum [INN-Latin]; Neomicina; Neomycin sulphate; Neomycine; Neomycinum; PIMAVECORT; Neomycine [INN-French]; Neomycinum [INN-Latin]; Framycetine [INN-French]; Framicetina [INN-Spanish]; Framycetin [INN:BAN:DCF]; Bycomycin; Jernadex; Framycetin (INN); Neomycin [INN:BAN]; EINECS 204-292-2; EINECS 215-766-3; EPA Pesticide Chemical Code 006303; BRN 0101621; Mycerin; Antibiotic 956; C23H46N6O13; NEOMYCINB; Antibiotic produced by Streptomyces decaris. Neomycin B; Prestwick3_000158; KDR Kinase Inhibitor, 3; BDBM19; SCHEMBL3279; ANTIBIOTIQUE EF 185; BSPBio_000296; GTPL709; 4-18-00-07476 (Beilstein Handbook Reference); BPBio1_000326; CHEMBL184618; DTXSID2023359; HMS2089P15; ZINC71928291; AKOS024284361; CS-6390; DB00452; NCGC00179612-01; HY-17624; ST075177; AB00443887; C01737; D05140; 30384-EP2272825A2; 30384-EP2272838A1; 30384-EP2277898A2; 30384-EP2287165A2; 30384-EP2287166A2; 30384-EP2292620A2; 30384-EP2295401A2; 30384-EP2295402A2; 30384-EP2298776A1; 30384-EP2305662A1; 30384-EP2305695A2; 30384-EP2305696A2; 30384-EP2305697A2; 30384-EP2305698A2; 30384-EP2311464A1; AB00443887-03; MYCIFRADIN; NEOMAS; PIMAVECORT; VONAMYCIN; J-004060; Q4492348; BRD-K71013094-065-01-2; UNII-I16QD7X297 component PGBHMTALBVVCIT-VCIWKGPPSA-N; 11004-65-2
Clinical Status
Approved
Disease Indication Hepatic encephalopathy ICD-11: DB99 [1]
PubChem CID
8378
Formula
C23H46N6O13
Canonical SMILES
C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N
InChI
1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey
PGBHMTALBVVCIT-VCIWKGPPSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=8378"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 614.6 Topological Polar Surface Area 353
XlogP -9 Complexity 872
Heavy Atom Count 42 Rotatable Bond Count 9
Hydrogen Bond Donor Count 13 Hydrogen Bond Acceptor Count 19
Full List of Drug Formulations (DFMs) Containing This API
          Neomycin 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Povidone; Silicon dioxide
                   Dosage Form Oral Tablet
                   Company ECI Pharmaceuticals; Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Calcium stearate; Povidone; Alcohol
                   Dosage Form Oral Tablet
                   Company Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Povidone
                   Dosage Form Oral Tablet
                   Company Hi-Tech Pharmacal; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Silicon dioxide; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Povidone k29/32
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals; X-GEN Pharmaceuticals
References
1 FDA label for approved neomycin from the official website of the U.S. Food and Drug Administration.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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