Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00479)
Name
Norfloxacin
Synonyms    Click to Show/Hide the Synonyms of This API
norfloxacin; 70458-96-7; Norfloxacine; Noroxin; Chibroxin; Baccidal; Sebercim; MK-366; Norfloxacinum; Norfloxacino; Barazan; Fulgram; AM-715; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Lexinor; Zoroxin; 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid; UNII-N0F8P22L1P; MFCD00079532; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid; CHEMBL9; CHEBI:100246; 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid; MLS000069650; N0F8P22L1P; NCGC00016916-01; NCGC00016916-09; SMR000058200; CAS-70458-96-7; DSSTox_CID_17680; DSSTox_RID_79353; DSSTox_GSID_37680; Norfloxacine [INN-French]; Norfloxacinum [INN-Latin]; Norfloxacino [INN-Spanish]; AM 715; norphloxacine; Norflo; MK 0366; 1-ethyl-6-fluoro-4-oxo-7-piperazinylhydroquinoline-3-carboxylic acid; Noroxin (TN); CCRIS 6302; SR-01000000222; EINECS 274-614-4; BRN 0567897; Chibroxine; Chibroxol; Gonorcin; Nolicin; Noracin; Noraxin; Norocin; Noroxine; Norxacin; Uroxacin; norfloxacine;; Utinor; HSDB 8029; Norfloxacine,(S); Prestwick_633; Norfloxacin [USAN:USP:INN:BAN:JAN]; Norfloxacin (Norxacin); Norfloxacin - Norxacin; Spectrum_001017; Opera_ID_1423; Prestwick0_000221; Prestwick1_000221; Prestwick2_000221; Prestwick3_000221; Spectrum2_001017; Spectrum3_000524; Spectrum4_000453; Spectrum5_001154; Epitope ID:119068; SCHEMBL3473; Oprea1_375152; BSPBio_000261; BSPBio_002107; KBioGR_000866; KBioSS_001497; MLS006011446; ARONIS24170; BIDD:GT0725; DivK1c_000084; SPECTRUM1500440; SPBio_001173; SPBio_002182; BPBio1_000289; ZINC3742; Norfloxacin (JP17/USP/INN); DTXSID7037680; BCBcMAP01_000218; HMS500E06; KBio1_000084; KBio2_001497; KBio2_004065; KBio2_006633; KBio3_001607; NINDS_000084; HMS1568N03; HMS1920B16; HMS2090F03; HMS2091J16; HMS2095N03; HMS2235G03; HMS3712N03; Pharmakon1600-01500440; ACT02630; ALBB-015911; BCP27734; EBD35051; HY-B0132; RKL10074; Tox21_110682; Tox21_113441; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid; ANW-42194; BBL005569; BDBM50045000; CCG-40235; NSC757250; SBB012542; STK177250; AKOS000417391; Tox21_110682_1; AC-6855; BCP9000993; CS-1906; DB01059; KS-5007; MCULE-1115657359; Norfloxacin, 98%, analytical standard; NSC-757250; 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic Acid; IDI1_000084; SMP1_000216; NCGC00016916-02; NCGC00016916-03; NCGC00016916-04; NCGC00016916-05; NCGC00016916-06; NCGC00016916-07; NCGC00016916-08; NCGC00016916-11; NCGC00016916-12; NCGC00021725-03; NCGC00021725-04; AK323673; ST072202; SY051390; Norfloxacin 100 microg/mL in Acetonitrile; SBI-0051464.P002; AB0012429; FT-0630800; FT-0673085; C06687; D00210; J10487; N-8650; Z-0833; AB00052059-18; AB00052059-19; AB00052059_20; AB00052059_21; Norfloxacin, analytical standard, >=98% (TLC); Norfloxacin, VETRANAL(TM), analytical standard; 458N967; Norfloxacin, Antibiotic for Culture Media Use Only; Q417897; SR-01000000222-2; SR-01000000222-3; BRD-K11196887-001-05-5; BRD-K11196887-001-15-4; Z56926638; Norfloxacin, British Pharmacopoeia (BP) Reference Standard; Norfloxacin, European Pharmacopoeia (EP) Reference Standard; 1-Ethyl-3-carboxy-6-fluoro-7-(piperazinyl-1)-quinolin-4(1H)-one; Norfloxacin, United States Pharmacopeia (USP) Reference Standard; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid; Norfloxacin, Pharmaceutical Secondary Standard; Certified Reference Material; 1-ethyl-1,4-dihydro-6-fluoro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid; 1-ethyl-4-oxo-6-fluoro-7-(piperazinyl)-1,4-dihydro-quinoline-3-carboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylicAcid; 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid; 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid; 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-piperazinyl-1,4-dihydro-quinoline-3-carboxylic acid; 1-ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 1-ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro)-4-oxo-7-(piperazinyl)-; 7-(1-Piperazinyl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Clinical Status
Approved
Disease Indication Infectious cystitis ICD-11: GC00 [1]
PubChem CID
4539
Formula
C16H18FN3O3
Canonical SMILES
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
InChI
1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChIKey
OGJPXUAPXNRGGI-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL 2D MOL
Physicochemical Properties Molecular Weight 319.33 Topological Polar Surface Area 72.9
XlogP -1 Complexity 519
Heavy Atom Count 23 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Norfloxacin 400 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses
                   Dosage Form Oral Tablet
                   Company Merck Sharp & Dohme
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
References
1 FDA label for approved norfloxacin from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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