Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00487)
Name
Olsalazine
Synonyms    Click to Show/Hide the Synonyms of This API
Olsalazine; 15722-48-2; Olsalazina; Olsalazinum; 5,5'-Azobis(salicylic acid); 3,3'-Azobis(6-hydroxybenzoic acid); UNII-ULS5I8J03O; ULS5I8J03O; (E)-5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoic acid); CHEBI:7770; Azodisal; mordant yellow 5; 3,3'-diazene-1,2-diylbis(6-hydroxybenzoic acid); Olsalazinum [Latin]; Olsalazina [Spanish]; Mirtazanine; Dipentium; Olsalazine [INN:BAN]; C.I. Mordant Yellow 5; Salicylic acid, 5,5'-azodi-; MFCD00013300; Olsalazine (INN); Benzoic acid, 3,3'-azobis(6-hydroxy-; 5,5'-azodisalicylic acid; CHEMBL425; C07323; SCHEMBL25118; SCHEMBL25119; SCHEMBL29768; C14H8N2Na2O6; BIDD:GT0392; SCHEMBL2628413; CHEMBL1208644; DTXSID8023391; ZINC3812865; ZINC12503280; ZINC95536736; ZINC100026052; ZINC245190568; AC-8144; DB01250; 5-[(2E)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid; 5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid; AS-15939; SY107522; D08295; 722O482; A809825; Q347621; Q-201512; 3,3'-(1,2-diazenediyl)Bis(6-Hydroxy-Benzoic Acid); 3,3'-(E)-diazene-1,2-diylbis(6-hydroxybenzoic acid); (Z)-5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoic acid); 5-[(E)-2-(3-carboxy-4-hydroxyphenyl)diazen-1-yl]-2-hydroxybenzoic acid; 5-[(2Z)-2-(3-carboxy-4-oxo-1-cyclohexa-2,5-dienylidene)hydrazinyl]-2-hydroxybenzoic acid; 1004301-38-5; 5-[(2Z)-2-(3-carboxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-oxidanyl-benzoic acid
Clinical Status
Approved
Disease Indication Ulcerative colitis ICD-11: DD71 [1]
PubChem CID
22419
Formula
C14H10N2O6
Canonical SMILES
C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)O)C(=O)O)C(=O)O)O
InChI
1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)
InChIKey
QQBDLJCYGRGAKP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=22419"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 302.24 Topological Polar Surface Area 140
XlogP 3.1 Complexity 415
Heavy Atom Count 22 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 8
Full List of Drug Formulations (DFMs) Containing This API
          Olsalazine 250 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferrosoferric oxide; Titanium dioxide; Caramel; Gelatin
                   Dosage Form Oral Capsule
                   Company Carilion Materials Management; MEDA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved olsalazine from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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