Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00497)
Name
Oxandrolone
Synonyms    Click to Show/Hide the Synonyms of This API
OXANDROLONE; Anavar; 53-39-4; Oxandrin; Vasorome; Lonavar; Protivar; Provitar; Ossandrolone [DCIT]; Oxandrolonum; Oxandrolona; Oxandrolonum [INN-Latin]; Oxandrolona [INN-Spanish]; SC 11585; SC-11585; UNII-7H6TM3CT4L; (4aS,4bS,6aS,7S,9aS,9bR,11aS)-7-hydroxy-4a,6a,7-trimethyltetradecahydroindeno[4,5-h]isochromen-2(1H)-one; 7H6TM3CT4L; CHEBI:7820; (1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one; Ossandrolone; Oxandrin (TN); 8075 C. B.; HSDB 3373; EINECS 200-172-9; NSC 67068; 8075 CB; 17beta-Hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one; Oxandrolone (JAN/USP/INN); 17beta-Hydroxy-17-methyl-2-oxa-5alpha-androstan-3-one; Oxandrin;Anavar; Oxandrolone ciii; NSC-67068; 2-Oxaandrostan-3-one, 17-hydroxy-17-methyl-, (5alpha,17beta)-; Dodecahydro-3-hydroxy-6-(hydroxy-methyl)-3,3a,6-trimethyl-1H-benz(e)indene-7-acetic acid delta-lactone; Oxandrolone [USAN:USP:INN:BAN:JAN]; 2-Oxa-5alpha-androstan-3-one, 17beta-hydroxy-17-methyl-; 8075 C.B.; SCHEMBL148881; GTPL7092; CHEMBL1200436; DTXSID8023399; Oxandrolone, >=98% (HPLC); 17-beta-hydroxy-17-methyl-2-oxa-androstan-3-one (9CI); 2-Oxa-5-alpha-androstan-3-one, 17-beta-hydroxy-17-methyl-; HMS3712E22; AOB87477; HY-B0707; ZINC3813047; AKOS025401400; AB04708; CCG-220110; DB00621; AC-14975; C07346; D00462; AB01559948-01; 198O944; Q420859; SR-01000872645; SR-01000872645-1; W-105740; 17alpha-Methyl-17beta-hydroxy-2-oxa-5alpha-androstan-3-one; 2-Oxa-5alpha-androstan-3-one, 17beta-hydroxy-17-methyl- (8CI); 2-Oxaandrostan-3-one, 17-hydroxy-17-methyl-, (5-alpha,17-beta)- (9CI); (1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyl-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
Clinical Status
Approved
Disease Indication Alcoholic hepatitis ICD-11: DB94 [1]
PubChem CID
5878
Formula
C19H30O3
Canonical SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(COC(=O)C4)C
InChI
1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1
InChIKey
QSLJIVKCVHQPLV-PEMPUTJUSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5878"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 306.4 Topological Polar Surface Area 46.5
XlogP 3.7 Complexity 503
Heavy Atom Count 22 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Oxandrolone 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Hypromellose, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Upsher-Smith Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Oxandrolone 2.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Hypromellose 2910 (15 mpa.s); Starch, corn
                   Dosage Form Oral Tablet
                   Company Watson Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved oxandrolone from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.