Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00544)
Name
Potassium citrate
Synonyms    Click to Show/Hide the Synonyms of This API
Potassium citrate; TRIPOTASSIUM CITRATE; 866-84-2; Potassium citrate anhydrous; 7778-49-6; Potassiumcitrate; Citric acid, tripotassium salt; UNII-86R1NVR0HW; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt; 86R1NVR0HW; Kaliksir; CHEBI:64733; Citric acid, potassium salt; tripotassium 2-hydroxypropane-1,2,3-tricarboxylate; tripotassium;2-hydroxypropane-1,2,3-tricarboxylate; Litocit; Porekal; Polycitra K; Urocit K; Seltz-K; C6H5K3O7; K citrate; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3); Potassium tribasic citrate; tripotassium citrate anhydrous; ACALKA; CCRIS 6566; HSDB 1248; EINECS 212-755-5; Potassium Citrate (anhydrous); EINECS 231-905-0; tri potassium citrate; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt; potassium citrate (anh.); anhydrous potassium citrate; EC 212-755-5; tripotassium citrate (anh.); anhydrous tripotassium citrate; INS NO.332(II); CHEMBL1200458; DTXSID8027325; tripotassium citrate (anhydrous); INS-332(II); 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?); E-332(II); citric acid tripotassium salt (anh.); AKOS015918285; DB09125; citric acid tripotassium salt (anhydrous); FT-0653076; 1334-EP2380568A1; potassium 2-hydroxypropane-1,2,3-tricarboxylate; A841790; Q419921; tripotassium 2-oxidanylpropane-1,2,3-tricarboxylate
Clinical Status
Approved
Disease Indication Urinary calculus ICD-11: GB70 [1]
PubChem CID
13344
Formula
C6H5K3O7
Canonical SMILES
C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+]
InChI
1S/C6H8O7.3K/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
InChIKey
QEEAPRPFLLJWCF-UHFFFAOYSA-K
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=13344"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 306.39 Topological Polar Surface Area 141
XlogP N.A. Complexity 211
Heavy Atom Count 16 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Potassium citrate 10 meq tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Carnauba wax
                   Dosage Form Extended Release Oral Tablet
                   Company Vensun Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Carnauba wax
                   Dosage Form Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Carnauba wax
                   Dosage Form Extended Release Oral Tablet
                   Company American Health Packaging; Cadila Healthcare; Physicians Total Care; RemedyRepack; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Potassium citrate 15 meq tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Carnauba wax
                   Dosage Form Extended Release Oral Tablet
                   Company Vensun Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Carnauba wax
                   Dosage Form Extended Release Oral Tablet
                   Company Cadila Healthcare; Physicians Total Care; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Potassium citrate 5 meq tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Carnauba wax
                   Dosage Form Extended Release Oral Tablet
                   Company Vensun Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Carnauba wax
                   Dosage Form Extended Release Oral Tablet
                   Company Cadila Healthcare; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved potassium citrate from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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