Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00569)
Name
Pyrantel
Synonyms    Click to Show/Hide the Synonyms of This API
PYRANTEL; 15686-83-6; Strongid; Pirantele [DCIT]; Pirantel; Pyrantelum; Pyrequan; Pyrantel [INN:BAN]; UNII-4QIH0N49E7; E-1,4,5,6-Tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine; (E)-1-Methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine; 4QIH0N49E7; CHEBI:8654; Pirantele; Pirantel [INN-Spanish]; Pyrantelum [INN-Latin]; HSDB 3252; EINECS 239-774-1; 2-[(1E)-2-(3-methyl(3,4,5,6-tetrahydropyrimidin-2-yl))vinyl]thiophene; Konvermex (TN); Pyrantel (INN); MLS006011881; SCHEMBL164730; CHEMBL1626223; DTXSID5023538; CHEBI:94685; ZINC97996; HMS1541D15; 1-methyl-2-[(E)-2-(2-thienyl)vinyl]-1,4,5,6-tetrahydropyrimidine; 1-methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine; SBB001723; STK676402; 1-methyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,5,6-tetrahydropyrimidine; AKOS005594318; Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-, (E)-; DB11156; NCGC00174007-01; NCGC00174007-02; SMR004703508; ST037147; C07409; D08451; AB00053538-07; AB00053538_08; Q426897; SR-01000802778; SR-01000802778-4; BRD-K20672254-046-02-1; BRD-K63072637-046-01-2; 1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]pyrimidine; 1-Methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine; 1,4,5,6-tetrahydro-1-methyl-2-[(1e)-2-(2-thienyl)ethenyl]-pyrimidine; 1-Methyl-2-[(E)-2-(2-thienyl)ethenyl]-1,4,5,6-tetrahydropyrimidine; 1-Methyl-2-[(E)-2-(2-thienyl)ethenyl]-1,4,5,6-tetrahydropyrimidine #; Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]-; Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (E)- (9CI)
Clinical Status
Approved
Disease Indication Hookworm disease ICD-11: 1F68 [1]
PubChem CID
708857
Formula
C11H14N2S
Canonical SMILES
CN1CCCN=C1/C=C/C2=CC=CS2
InChI
1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+
InChIKey
YSAUAVHXTIETRK-AATRIKPKSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=708857"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 206.31 Topological Polar Surface Area 43.8
XlogP 1.6 Complexity 248
Heavy Atom Count 14 Rotatable Bond Count 2
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Pyrantel 180 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Anhydrous dibasic calcium phosphate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company ProMex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
References
1 FDA label for approved pyrantel from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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