Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00633)
Name
Sodium phenylbutyrate
Synonyms    Click to Show/Hide the Synonyms of This API
Sodium 4-phenylbutyrate; SODIUM PHENYLBUTYRATE; 1716-12-7; sodium 4-phenylbutanoate; Buphenyl; TriButyrate; Ammonaps; Benzenebutanoic acid, sodium salt; 4-Phenylbutyric Acid Sodium Salt; 4-phenylbutyric acid sodium; Phenylbutyrate; UNII-NT6K61736T; sodium;4-phenylbutanoate; CHEBI:75316; NT6K61736T; MFCD00800247; DSSTox_CID_20948; DSSTox_RID_79606; DSSTox_GSID_40948; 4-Phenylbutyrate, Na; C10H11NaO2; CAS-1716-12-7; NSC-657802; NCGC00018113-03; NSC 657802; Ammonapse; Lunaphen; Phenylbutyrate Na; 4-phenylbutyric acid, sodium salt; Sodium phenylbutyrate [USAN:BAN]; Buphenyl (TN); EL-532; VP-101; sodium-4-phenylbutyrate; CHEMBL1746; Phenylbutyric acid sodium salt; SCHEMBL125792; ACER-001; Sodium 4-phenylbutyrate, 95%; DTXSID7040948; CMK-304; Sodium phenylbutyrate (JAN/USP); HMS2089B22; HMS3269N07; HMS3413B10; HMS3652K18; HMS3677B10; HMS3885P05; Sodium 4-phenylbutyrate;TriButyrate; Tox21_110826; CS0031; AKOS006344763; AKOS015967141; Tox21_110826_1; CCG-213730; CCG-265014; CS-1397; Sodium phenylbutyrate, >=98% (HPLC); NCGC00018113-07; NCGC00167830-01; AK-93011; AS-13914; HY-15654; SY067225; AB0013057; FT-0619402; SW219199-1; AMX0035 COMPONENT SODIUM PHENYLBUTYRATE; D05868; M-2491; AMX-0035 COMPONENT SODIUM PHENYLBUTYRATE; J-010746; J-524277; Q7553358; Sodium phenylbutyrate, European Pharmacopoeia (EP) Reference Standard; Sodium phenylbutyrate, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
Disease Indication Muscular atrophy ICD-11: 8B61 [1]
PubChem CID
5258
Formula
C10H11NaO2
Canonical SMILES
C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
InChI
1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
InChIKey
VPZRWNZGLKXFOE-UHFFFAOYSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5258"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 186.18 Topological Polar Surface Area 40.1
XlogP N.A. Complexity 142
Heavy Atom Count 13 Rotatable Bond Count 4
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Sodium phenylbutyrate 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Hyperion Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Mikart
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved sodium phenylbutyrate from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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