Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00696)
Name
Tranexamic acid
Synonyms    Click to Show/Hide the Synonyms of This API
tranexamic acid; 1197-18-8; Cyklokapron; trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamsaeure; 4-(Aminomethyl)cyclohexanecarboxylic acid; Amstat; Trans AMCHA; Tranhexamic acid; Transamin; Tamcha; trans-Amcha; Amikapron; Anvitoff; Cyclocapron; Ugurol; 701-54-2; Frenolyse; Rikavarin; Trasamlon; Carxamin; Emorhalt; Tranexan; Mastop; Rikavarin-S; 1197-17-7; Exacyl; tranexmic acid; Hexapromin; Transamlon; Hexatron; Spiramin; Tranex; trans-4-Aminomethylcyclohexane-1-carboxylic acid; cis-4-(Aminomethyl)cyclohexanecarboxylic acid; trans-Tranexamic acid; Acidum tranexamicum; 4-(aminomethyl)cyclohexane-1-carboxylic acid; cis-Tranexamic Acid; Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-; Acido tranexamico; Acide tranexamique; CL 65336; Lysteda; BAY 3517; RP 18,429; cis-4-Aminomethylcyclohexane-1-carboxylic acid; 4-(Aminomethyl)-Cyclohexanecarboxylic Acid; Cyclohexanecarboxylic acid, 4-(aminomethyl)-; trans-p-(Aminomethyl)cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 4-(aminomethyl)-, cis-; MFCD00001466; UNII-37YD696II6; UNII-6T84R30KC1; CL-65336; trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid; trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid; (1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic acid; trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid; Tranexamic acid (Transamin); Retavase; CHEBI:48669; 37YD696II6; 6T84R30KC1; LB1148; NSC291305; trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester; 4-aminomethylcyclohexanecarboxylic acid; NSC-291305; cis-AMCHA; NCGC00016569-01; CAS-1197-18-8; Tranexamic acid, 98+%; Tranexamic acid cis-form; Acide tranexamique [INN-French]; Acido tranexamico [INN-Spanish]; Acidum tranexamicum [INN-Latin]; Cyklokapron (TN); Rikavarin (TN); Transamin (TN); SR-05000001794; EINECS 214-818-2; trans-1-Aminomethylcyclohexane-4-carboxylic acid; NSC 291305; BRN 2207452; tranexamate; Femstrual; Cyclo-F; Prestwick_476; ALBB-006013; Tranexamic Acid,(S); PubChem19810; Spectrum_001391; Tranexamic acid [USAN:USP:INN:BAN:JAN]; Prestwick0_000171; Prestwick1_000171; Prestwick2_000171; Prestwick3_000171; Spectrum2_000655; Spectrum3_001189; Spectrum4_000046; Spectrum5_001258; ACMC-209a3u; ACMC-20h19o; CHEMBL877; trans-4-(Aminomethyl)cyclohexane-carboxylic acid; DSSTox_CID_25350; DSSTox_RID_80817; cis-4-(aminomethyl)cyclohexane-1-carboxylic acid; DSSTox_GSID_45350; Oprea1_786414; SCHEMBL16974; BSPBio_000061; BSPBio_002837; KBioGR_000511; KBioSS_001871; 3-14-00-00868 (Beilstein Handbook Reference); 701-54-2 tranexamic acid; DivK1c_000655; SCHEMBL186034; SCHEMBL349408; SPECTRUM1502026; SPBio_000689; SPBio_001982; BPBio1_000069; CHEMBL292500; GTPL6573; SCHEMBL6885575; SCHEMBL9885628; 701-54-2 (cis+trans); FMOC-(R)-2-aminobutyric acid; DTXSID3045350; CHEBI:94518; HMS502A17; KBio1_000655; KBio2_001871; KBio2_004439; KBio2_007007; KBio3_002337; DTXSID50904827; WLN: L6TJ AVQ D1Z -T; NINDS_000655; HMS1568D03; HMS1921F08; HMS2092P03; HMS2095D03; HMS3712D03; HMS3744G07; Pharmakon1600-01502026; BCP13133; BCP18146; HY-B0149; Tranexamic acid (JP17/USP/INN); ZINC1542907; Tox21_110500; ANW-17368; BBL004469; BDBM50428067; CCG-39692; HTS001347; MFCD00064951; MFCD19706018; NSC758176; SBB006715; STK503668; Tranexamic Acid(Random Configuration); AKOS005171632; AKOS015854573; AKOS024257901; ZINC100007011; ZINC100071256; AC-4687; AM84352; BS-3867; CS-1965; DB00302; MCULE-6087008336; NSC-758176; 4-Aminomethyl-cyclohexanecarboxylic acid; TAMCHA; IDI1_000655; NCGC00016569-02; NCGC00016569-03; NCGC00016569-04; NCGC00016569-05; NCGC00016569-06; NCGC00016569-08; NCGC00016569-09; NCGC00094944-01; NCGC00094944-02; p-(Aminomethyl)cyclohexanecarboxylic acid; AK134863; AK308472; BP-12345; RP-18429; SY011438; TS-02090; SBI-0051705.P002; trans 4aminomethylcyclohexanecarboxylic acid; AB0013391; DB-074265; Trans-4-aminomethylcyclohexylcarboxylic acid; trans-p-Aminomethylcyclohexanecarboxylic acid; AB00052260; BB 0260034; CS-0013687; CS-0055045; FT-0654339; FT-0675360; FT-0700806; ST50307111; trans 4-aminomethylcyclohexanecarboxylic acid; trans-4-aminomethylcyclohexanecarboxylic acid; EN300-91506; trans-4(aminomethyl)cyclohexanecarboxylic acid; trans-4-(aminomethyl)cyclohexylcarboxylic acid; trans-4-aminomethyl cyclohexanecarboxylic acid; trans-4-aminomethyl-cyclohexanecarboxylic acid; trans-4-aminomethylcyclohexane carboxylic acid; C-5054; C12535; D01136; Q-9390; Trans-4-Aminomethyl cyclohexane carboxylic acid; trans4-aminomethylcyclohexane-1-carboxylic acid; AB00052260-04; AB00052260_05; AB00052260_06; trans-4 -(aminomethyl)cyclohexanecarboxylic acid; trans-4-(aminomethyl)-cyclohexanecarboxylic acid; trans-4-(Aminomethyl)cyclohexane carboxylic acid; trans-4-aminomethyl-1-cyclohexanecarboxylic acid; (1r,4r)-4-(aminomethyl)cyclohexanecarboxylic acid; (trans)-4-(aminomethyl)cyclohexanecarboxylic acid; 197T188; 204139-EP2277867A2; 204139-EP2280003A2; 4-(Aminomethyl)cyclohexanecarboxylic acid (trans-); 4-trans-(Aminomethyl)cyclohexanecarboxylic acid #; Q418666; trans-?4-?(Aminomethyl)?cyclohexanecarboxylic acid; trans-4- (aminomethyl) cyclohexanecarboxylic acid; trans-4-(aminomethyl)- cyclohexane carboxylic acid; Trans-4-(aminomethyl)-cyclohexane carboxylic acid; trans-4-aminomethyl-1-cyclohexane carboxylic acid; 4alpha-Aminomethyl-1alpha-cyclohexanecarboxylic acid; CIS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLICACID; Q-201848; SR-05000001794-1; SR-05000001794-2; SR-05000001794-3; BRD-K15014948-001-01-2; Q27256710; trans-4-(Aminomethyl)cyclohexanecarboxylic acid, 97%; 4-(Aminomethyl)cyclohexanecarboxylic acid;Tranexamic acid; F8886-7867; Z1741970429; rel-(1R,4R)-4-(aminomethyl)cyclohexane-1-carboxylic acid; Tranexamic acid, European Pharmacopoeia (EP) Reference Standard; Tranexamic acid, United States Pharmacopeia (USP) Reference Standard; trans-4-(Aminomethyl)cyclohexanecarboxylic acid (Tranexamic acid); 4-(Aminomethyl)cyclohexanecarboxylic acid (cis- and trans- mixture);; Tranexamic acid, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status
Approved
Disease Indication Excessive bleeding ICD-11: GA30 [1]
PubChem CID
5526
Formula
C8H15NO2
Canonical SMILES
C1CC(CCC1CN)C(=O)O
InChI
1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
InChIKey
GYDJEQRTZSCIOI-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5526"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 157.21 Topological Polar Surface Area 63.3
XlogP -2 Complexity 139
Heavy Atom Count 11 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Tranexamic acid 650 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose, unspecified form; Magnesium stearate; Silicon dioxide; Hypromelloses; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amring Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Ferring Pharmaceuticals; Prasco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Ferring Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Glyceryl dibehenate; Magnesium stearate; Talc; Triethyl citrate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Copovidone; Dimethylaminoethyl methacrylate - butyl methacrylate - methyl methacrylate copolymer; Hypromellose, unspecified; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Glyceryl dibehenate; Magnesium stearate; Talc; Triethyl citrate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Copovidone k25-31; Dimethylaminoethyl methacrylate - butyl methacrylate - methyl methacrylate copolymer; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Ethylcelluloses
                   Dosage Form Oral Tablet
                   Company Apotex; Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved tranexamic acid from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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