Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00704) | |||||
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Name |
Trihexyphenidyl
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Synonyms |
Click to Show/Hide the Synonyms of This API
trihexyphenidyl; Benzhexol; Triphenidyl; Parkinane retard; 144-11-6; Trihexyphenidyle; Sedrena (free base); Trihexyphenidylum; Trihexifenidilo [INN-Spanish]; Trihexyphenidyle [INN-French]; Trihexyphenidylum [INN-Latin]; 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol; Benzhexol free base; Benzhexolum; 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol; 1-Piperidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-; CHEBI:9720; 144-11-6 (free base); NSC-12268; Trihexifenidilo; Trihexylphenedyl; Trihexylphenidyl; Trihexylphenizyl; Trihexylphenidyle; (+/-)-Triphenidyl; Benzhexol; NSC 12268; Trihexyphenidyl [INN:BAN]; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-,; Apo-trihex (TN); HSDB 3196; Trihexyphenidyl (INN); EINECS 205-614-4; NSC 12268; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; BRN 0088959; 40520-25-0; (?)-Benzhexol; Spectrum_000632; Prestwick0_000701; Prestwick1_000701; Prestwick2_000701; Prestwick3_000701; Spectrum2_000829; Spectrum3_001375; Spectrum4_000369; Spectrum5_001465; CHEMBL1490; Lopac0_001125; Oprea1_853391; SCHEMBL34645; BSPBio_000881; BSPBio_002930; KBioGR_000837; KBioSS_001112; 5-20-02-00231 (Beilstein Handbook Reference); DivK1c_000372; SPBio_000757; SPBio_002802; BPBio1_000971; GTPL7315; DTXSID4023705; BDBM81462; KBio1_000372; KBio2_001112; KBio2_003680; KBio2_006248; KBio3_002150; NINDS_000372; NSC_5572; NSC12268; BBL024959; STL300356; AKOS015914081; CCG-205200; DB00376; MCULE-6065307656; SDCCGSBI-0051093.P004; IDI1_000372; MRF-0000523; NCGC00016003-03; NCGC00016003-04; NCGC00016003-06; NCGC00016003-07; NCGC00016003-15; NCGC00089797-02; SBI-0051093.P003; CAS_58947-95-8; AB00053559; C07171; D08638; AB00053559_13; 119618-EP2269989A1; 119618-EP2298731A1; 144T116; L000821; Q2991856; BRD-A48180038-003-05-2; BRD-A48180038-003-15-1; .alpha.-Cyclohexyl-.alpha.-phenyl-1-piperidinepropanol; 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol #; (R)-1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
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Clinical Status |
Approved
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Disease Indication | Parkinsonism | ICD-11: 8A00 | [1] | ||
PubChem CID | |||||
Formula |
C20H31NO
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Canonical SMILES |
C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
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InChI |
1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2
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InChIKey |
HWHLPVGTWGOCJO-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5572"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 301.5 | Topological Polar Surface Area | 23.5 | |
XlogP | 4.5 | Complexity | 314 | ||
Heavy Atom Count | 22 | Rotatable Bond Count | 5 | ||
Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 2 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Trihexyphenidyl 2 mg tablet | Click to Show/Hide the Full List of Formulation(s): 8 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Actavis Pharma; Kaiser Foundation Hospitals; RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | NCS HealthCare of KY, Inc dba Vangard Labs | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Carilion Materials Management | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 6 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack; West-Ward Pharmaceticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 7 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Avera McKennan Hospital; Natco Pharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 8 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | American Health Packaging; Clinical Solutions Wholesale; Qualitest Pharmaceuticals; RemedyRepack; Richmond Pharmaceuticals; Rising Pharmaceuticals; State of Florida DOH Central Pharmacy | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Trihexyphenidyl 5 mg tablet | Click to Show/Hide the Full List of Formulation(s): 8 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Actavis Pharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | NCS HealthCare of KY, Inc dba Vangard Labs | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Calcium phosphate, dibasic, dihydrate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | State of Florida DOH Central Pharmacy | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 6 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack; West-Ward Pharmaceticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 7 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | Natco Pharma; RemedyRepack; TYA Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Drug Formulation 8 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | American Health Packaging; Clinical Solutions Wholesale; Qualitest Pharmaceuticals; RemedyRepack; Richmond Pharmaceuticals; Rising Pharmaceuticals; State of Florida DOH Central Pharmacy | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
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