General Information of API (ID: D00704)
Name
Trihexyphenidyl
Synonyms    Click to Show/Hide the Synonyms of This API
trihexyphenidyl; Benzhexol; Triphenidyl; Parkinane retard; 144-11-6; Trihexyphenidyle; Sedrena (free base); Trihexyphenidylum; Trihexifenidilo [INN-Spanish]; Trihexyphenidyle [INN-French]; Trihexyphenidylum [INN-Latin]; 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol; Benzhexol free base; Benzhexolum; 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol; 1-Piperidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-; CHEBI:9720; 144-11-6 (free base); NSC-12268; Trihexifenidilo; Trihexylphenedyl; Trihexylphenidyl; Trihexylphenizyl; Trihexylphenidyle; (+/-)-Triphenidyl; Benzhexol; NSC 12268; Trihexyphenidyl [INN:BAN]; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-,; Apo-trihex (TN); HSDB 3196; Trihexyphenidyl (INN); EINECS 205-614-4; NSC 12268; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; BRN 0088959; 40520-25-0; (?)-Benzhexol; Spectrum_000632; Prestwick0_000701; Prestwick1_000701; Prestwick2_000701; Prestwick3_000701; Spectrum2_000829; Spectrum3_001375; Spectrum4_000369; Spectrum5_001465; CHEMBL1490; Lopac0_001125; Oprea1_853391; SCHEMBL34645; BSPBio_000881; BSPBio_002930; KBioGR_000837; KBioSS_001112; 5-20-02-00231 (Beilstein Handbook Reference); DivK1c_000372; SPBio_000757; SPBio_002802; BPBio1_000971; GTPL7315; DTXSID4023705; BDBM81462; KBio1_000372; KBio2_001112; KBio2_003680; KBio2_006248; KBio3_002150; NINDS_000372; NSC_5572; NSC12268; BBL024959; STL300356; AKOS015914081; CCG-205200; DB00376; MCULE-6065307656; SDCCGSBI-0051093.P004; IDI1_000372; MRF-0000523; NCGC00016003-03; NCGC00016003-04; NCGC00016003-06; NCGC00016003-07; NCGC00016003-15; NCGC00089797-02; SBI-0051093.P003; CAS_58947-95-8; AB00053559; C07171; D08638; AB00053559_13; 119618-EP2269989A1; 119618-EP2298731A1; 144T116; L000821; Q2991856; BRD-A48180038-003-05-2; BRD-A48180038-003-15-1; .alpha.-Cyclohexyl-.alpha.-phenyl-1-piperidinepropanol; 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol #; (R)-1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
Clinical Status
Approved
Disease Indication Parkinsonism ICD-11: 8A00 [1]
PubChem CID
5572
Formula
C20H31NO
Canonical SMILES
C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
InChI
1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2
InChIKey
HWHLPVGTWGOCJO-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5572"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 301.5 Topological Polar Surface Area 23.5
XlogP 4.5 Complexity 314
Heavy Atom Count 22 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Trihexyphenidyl 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Actavis Pharma; Kaiser Foundation Hospitals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Natco Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Clinical Solutions Wholesale; Qualitest Pharmaceuticals; RemedyRepack; Richmond Pharmaceuticals; Rising Pharmaceuticals; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Trihexyphenidyl 5 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Calcium phosphate, dibasic, dihydrate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Natco Pharma; RemedyRepack; TYA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Clinical Solutions Wholesale; Qualitest Pharmaceuticals; RemedyRepack; Richmond Pharmaceuticals; Rising Pharmaceuticals; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved trihexyphenidyl from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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