Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00705)
Name
Trimethadione
Synonyms    Click to Show/Hide the Synonyms of This API
trimethadione; 127-48-0; Tridione; Troxidone; Trimetadione; Trimethadion; Trimetin; Absentol; Convenixa; Convexina; Epidione; Petidion; Petimalin; Tioxanona; Tridilona; Trimedal; Trimethin; Trioxanona; Absetil; Epixal; Petidon; Petilep; Ptimal; Tridion; Minoaleviatin; Trimethdione; Minoaleuiatin; Tredione; Tricione; Trilidona; Trimedone; Triozanona; Tromedone; Epidone; Etydion; Pitmal; Tridone; 3,5,5-Trimethyloxazolidine-2,4-dione; 2,4-OXAZOLIDINEDIONE, 3,5,5-TRIMETHYL-; 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione; 3,5,5-Trimethyl-2,4-oxazolidinedione; Mino-Aleviatin; 3,5,5,-Trimethyloxazolidine-2,4-dione; A 2297; 3,3,5-Trimethyl-2,4-diketooxazolidine; UNII-R7GV3H6FQ4; NSC 15799; 3,5,5-Trojmetylooksazolidyno-2,4-dion; R7GV3H6FQ4; Trimethinum; Trioksal; 3,5,5-TRIMETHYL-OXAZOLIDINE-2,4-DIONE; trimethyl-1,3-oxazolidine-2,4-dione; NCGC00016383-01; Trimetadiona; Trimethadionum; CAS-127-48-0; Trimetadione [DCIT]; DSSTox_CID_1396; 2, 3,5,5-trimethyl-; DSSTox_RID_76137; DSSTox_GSID_21396; Trimetadiona [INN-Spanish]; Trimethadionum [INN-Latin]; 3,5-Trimethyl-2,4-oxazolidinedione; 3,5-Trimethyl-2,4-diketooxazolidine; WLN: T5OVNV EHJ C1 E1 E1; Tridione (TN); EINECS 204-845-8; 3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish]; BRN 0121627; Mino aleviatin; Tridione Dulcet; Trimethadione [USP:INN:BAN:JAN]; Prestwick_815; MFCD00047084; ACMC-1BYOW; Prestwick0_000515; Prestwick1_000515; Prestwick2_000515; Prestwick3_000515; CHEMBL695; Trimethadione (JP17/INN); SCHEMBL28882; BSPBio_000469; MLS001076685; SPBio_002390; BPBio1_000517; CHEBI:9727; GTPL7316; DTXSID9021396; IRYJRGCIQBGHIV-UHFFFAOYSA-; HMS1569H11; HMS2093D10; HMS2096H11; HMS2235E12; HMS3713H11; HMS3886I12; Pharmakon1600-01505466; HY-A0092; NSC15799; ZINC1530710; Tox21_110408; Tox21_200231; BDBM50227239; NSC-15799; NSC169503; NSC759152; Trimethadione 1.0 mg/ml in Methanol; AKOS006229172; CCG-213460; DB00347; MCULE-4761457520; NSC-169503; NSC-759152; 3,5,5-Trimethyl oxazolidine-2,4-dione; NCGC00016383-02; NCGC00016383-03; NCGC00016383-05; NCGC00257785-01; BS-15128; SMR000499583; SBI-0206923.P001; FT-0694585; ST50411784; D00392; 20503-EP2275420A1; 20503-EP2280008A2; 20503-EP2298764A1; 20503-EP2298765A1; 20503-EP2308867A2; 20503-EP2308870A2; 20503-EP2314585A1; 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione #; Q827916; SR-01000763540; J-005496; SR-01000763540-2; BRD-K16606819-001-07-7; 3,5,5,-Trimethyloxazolidine-2,4-dione, analytical standard; Trimethadione, European Pharmacopoeia (EP) Reference Standard; Trimethadione, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
Disease Indication Epilepsy ICD-11: 8A60 [1]
PubChem CID
5576
Formula
C6H9NO3
Canonical SMILES
CC1(C(=O)N(C(=O)O1)C)C
InChI
1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
InChIKey
IRYJRGCIQBGHIV-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5576"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 143.14 Topological Polar Surface Area 46.6
XlogP 0.3 Complexity 197
Heavy Atom Count 10 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Trimethadione 150 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Magnesium trisilicate; Sucrose; Starch, corn
                   Dosage Form Chewable Tablet
                   Company AbbVie
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved trimethadione from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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