Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00711)
Name	Ulipristal acetate
Synonyms	Click to Show/Hide the Synonyms of This API Ulipristal acetate; 126784-99-4; EllaOne; CDB-2914; Ulipristal (acetate); CDB 2914; HRP 2000; UNII-YF7V70N02B; VA2914; (8S,11R,13S,14S,17R)-17-acetyl-11-(4-(dimethylamino)phenyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate; YF7V70N02B; CHEBI:71025; 17-Acetoxy-11-(4-N,N-dimethylaminophenyl)pregna-4,9-diene-3,20-dione; (11beta)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione; C30H37NO4; (11b)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione; (11beta)-17-(Acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione; (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-yl acetate; 17beta-acetyl-11beta-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17alpha-yl acetate; Ulipristal acetate [USAN]; Hrp-2000; Ulipristal acet; MFCD00899035; Ulipristal-Acetate; EllaOne; CBD 2914; Ella (TN); RTI 3021-012; C17 Epi Ulipristal Acetate; SCHEMBL544957; CHEMBL260538; GTPL7460; Ulipristal acetate (JAN/USAN); DTXSID30155294; ta[a]phenanthren-17-yl] acetate; [(8s,11r,13s,14s,17r)-17-Acetyl-11-[4-(Dimethylamino)phenyl]-13-Methyl-3-Oxo-1,2,6,7,8,11,12,14,15,16-Decahydrocyclopenta[a]phenanthren-17-Yl] Acetate; PGL-4001; ZINC3920657; BDBM50375424; Ulipristal acetate, >=98% (HPLC); AKOS026750526; CCG-269500; CS-1157; NCGC00378913-02; [(8S,11R,13S,14S,17R)-17-acetyl-11-(4-dimethylaminophenyl)-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate; AS-73950; HY-16508; RTI-3021-012; D09687; W-5201; AB01566874_01; 784A994; Q975059; J-005436; BRD-K64381438-001-03-8; Z2216208644; 5-(Hydroxymethyl)-alpha,alpha,alpha,alpha-tetramethyl-1,3-benzenediacetonitrile; (10S,11S,14R,15S,17R)-14-acetyl-17-[4-(dimethylamino)phenyl]-15-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-14-yl acetate; (11alpha,13alpha,17beta)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-yl acetate; (11beta)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione / CDB-2914; (1R,3aS,3bS,10R,11aS)-1-acetyl-10-[4-(dimethylamino)phenyl]-11a-methyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate; [(8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopen; 19-Norpregna-4,9-diene-3,20-dione, 17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-, (11beta)-; C17 Isomer Ulipristal Acetate; (10S,11S,14S,15S,17R)-14-Acetyl-17-[p-(dimethylamino)phenyl]-15-methyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadeca-1,6-dien-14-yl acetate; CBD 2914; VA 2914; (11b)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione
Clinical Status	Approved
Disease Indication	Contraception		ICD-11: JA65	[1]
PubChem CID	130904
Formula	C30H37NO4
Canonical SMILES	CC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)OC(=O)C
InChI	1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1
InChIKey	OOLLAFOLCSJHRE-ZHAKMVSLSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=130904"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	475.6	Topological Polar Surface Area	63.7
	XlogP	3.5	Complexity	984
	Heavy Atom Count	35	Rotatable Bond Count	5
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	5

Full List of Drug Formulations (DFMs) Containing This API
Ulipristal acetate 30 mg tablet			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Povidone k30
Dosage Form	Oral Tablet
Company	Afaxys Pharma; Watson Pharma
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[2]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[2]

References
1	FDA label for approved ulipristal acetate from the official website of the U.S. Food and Drug Administration.
2	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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