Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00971)
Name
Cromolyn
Synonyms    Click to Show/Hide the Synonyms of This API
cromolyn; Cromoglicic acid; 16110-51-3; Cromoglycate; Cromoglycic acid; Cromoglicate; Intal; Acido cromoglicico; Acide cromoglicique; Acidum cromoglicicum; 5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylic acid); UNII-Y0TK0FS77W; Aarane; Acide cromoglicique [INN-French]; Acido cromoglicico [INN-Spanish]; Acidum cromoglicicum [INN-Latin]; Y0TK0FS77W; 5-[3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid; CHEBI:59773; Aararre; Frenasma; Lomudal; Lomudas; Lomusol; Nalcrom; Nebulasma; Opticrom; Rynacrom; Nasmil; 1,3-Bis(2-carboxychromon-5-yloxy)-2-hydroxypropane; Cromo asma aerosol; Dinatrium cromoglicicum; 4H-1-Benzopyran-2-carboxylic acid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-; 5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylic acid); 1,3-Di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol; 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-; 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylic acid); FPL 670; 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid; Sodium Chromoglycate; 5,5'-(2-Hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic acid); NSC109500; NCGC00021142-02; Chromoglycate; Chromolyn; Cromoglicic acid [INN:BAN]; cromoglicic-acid; HSDB 3308; 5-(3-((2-Carboxy-4-oxo-4H-chromen-5-yl)oxy)-2-hydroxypropoxy)-4-oxo-4H-chromene-2-carboxylic acid; 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid; EINECS 240-279-8; C23H16O11; Cromo-Comod (TN); Spectrum_000852; Cromoglicic acid (INN); Cromolyn;Cromoglicic acid; Prestwick0_000812; Prestwick1_000812; Prestwick2_000812; Prestwick3_000812; Spectrum2_001137; Spectrum3_000367; Spectrum4_000302; Spectrum5_000791; SCHEMBL3865; Oprea1_077850; BSPBio_000703; BSPBio_002093; KBioGR_000884; KBioSS_001332; BIDD:GT0397; DivK1c_000857; SPBio_001033; SPBio_002624; BPBio1_000775; CHEMBL428880; GTPL7608; DTXSID4022860; KBio1_000857; KBio2_001332; KBio2_003900; KBio2_006468; KBio3_001313; R03BC01; NINDS_000857; ZINC1530788; ANW-71958; BDBM50440033; MFCD00864784; AKOS015961001; DB01003; 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-; IDI1_000857; ETHYLENEDIAMINEDI-L-(+)-TARTRATE; NCGC00021142-01; NCGC00159523-01; AC-12785; NCI60_000229; O542; SBI-0051323.P003; FT-0601561; 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol; C06928; D07753; 1,3-bis-(2-carboxychromon-5-yloxy)propan-2-ol; Q416427; J-009783; BRD-K20920669-304-06-7; 4H-1-Benzopyran-2-carboxylic acid, 5, {5'-[(2-hydroxytrimethylene)dioxy]bis(4-oxo-,}; 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo- (8CI); 5,5'-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylic acid); 105878-73-7; 4H-1-Benzopyran-2-carboxylic acid, {5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-,}; 5-[3-(2-carboxy-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylic acid
Clinical Status
Approved
PubChem CID
2882
Formula
C23H16O11
Canonical SMILES
C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O
InChI
1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30)
InChIKey
IMZMKUWMOSJXDT-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2882"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 468.4 Topological Polar Surface Area 166
XlogP 1.9 Complexity 835
Heavy Atom Count 34 Rotatable Bond Count 8
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 11
Full List of Drug Formulations (DFMs) Containing This API
          Cromolyn 0.8mg/inh aerosol Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cromolyn Sodium; Sorbitan Trioleate; Dichlorotetrafluoroethane; Dichlorodifluoromethane
                   Dosage Form Aerosol
                   Company King Pharms
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sorbitan trioleate DIG Info Protein kinase C theta (EC50 = 8670 nM) [1]
          Cromolyn 10mg/ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Purified Water
                   Dosage Form Solution
                   Company King Pharms
References
1 Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C. Bioorg Med Chem. 2010 Feb 15; 18(4):1591-8.

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