Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01065)
Name	Etomidate
Synonyms	Click to Show/Hide the Synonyms of This API Etomidate; 33125-97-2; (+)-Etomidate; Hypnomidate; D-Etomidate; Amidate; Etomidato; Etomidatum; (R)-ETHYL 1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLATE; ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate; ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate; Radenarcon; UNII-Z22628B598; (+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate; R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate; CHEMBL681; R 16659; (R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester; Amidate (pharmaceutical); CHEBI:4910; (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester; 1H-Imidazole-5-carboxylic acid, 1-[(1R)-1-phenylethyl]-, ethyl ester; 3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester; Z22628B598; 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)- [CAS]; (d)-Etomidate; Lipuro; Etomidic acid; Etomidatum [INN-Latin]; Etomidato [INN-Spanish]; 1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, ethyl ester; SMR000466277; Amidate (TN); 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester; MFCD00869295; Etomidate [USAN:USP:INN:BAN]; R(+)-etomidate; EINECS 251-385-9; R-ETOMIDATE; BRN 0665833; Etomidate (USP/INN); 1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester; SCHEMBL39487; MLS000758268; MLS001424163; GTPL5463; ZINC1408; 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (+)-; ethyl (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate; Etomidate 0.1 mg/ml in Methanol; Etomidate 1.0 mg/ml in Methanol; 1-(1-Phenylethyl)-imidazole-5-carboxylic acid, ethyl ester; HMS2051P18; HMS2232A08; HMS3267N06; HMS3412D11; HMS3676D11; HY-B0100; Etomidate, >98% (HPLC), powder; BDBM50125935; AKOS015920052; 33125-97-2 (net); CCG-101054; CS-1833; DB00292; GS-3208; NC00304; NCGC00025176-01; AM803710; AB0012165; E0897; C07522; D00548; J10465; S-3872; AB00639951_06; 125E972; A821630; Q418445; R-16659; SR-01000597569; Q-201102; SR-01000597569-1; BRD-K55055802-001-10-2; Etomidate, European Pharmacopoeia (EP) Reference Standard; r-(+)-ethyl-1-(1-phenylethyl)-1h-imidazole-5-carboxylate; 3-[(1R)-1-phenylethyl]-4-imidazolecarboxylic acid ethyl ester; Ethyl (R)-(+)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylate; Etomidate, United States Pharmacopeia (USP) Reference Standard; (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylicacid ethyl ester; (R)-(+)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic Acid Ethyl Ester; Imidazole-5-carboxylic acid, 1-(alpha-methylbenzyl)-, ethyl ester, (R)-(+)-; V8D
Clinical Status	Approved
PubChem CID	667484
Formula	C14H16N2O2
Canonical SMILES	CCOC(=O)C1=CN=CN1[C@H](C)C2=CC=CC=C2
InChI	1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
InChIKey	NPUKDXXFDDZOKR-LLVKDONJSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=667484"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	244.29	Topological Polar Surface Area	44.1
	XlogP	3	Complexity	277
	Heavy Atom Count	18	Rotatable Bond Count	5
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	3

Full List of Drug Formulations (DFMs) Containing This API
Etomidate 2mg/ml injectable			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Propylene Glycol
Dosage Form	Injectable
Company	Hospira
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Propylene glycol	DIG Info	Albendazole monooxygenase (Inhibition ratio < 20 %)	[1]

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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