Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET01FXQ)
Name
Cervical cancer HeLa cells (HeLa)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human endocervical cancer HeLa cells; HELA; Hela; He La; He-La; Henrietta Lacks cells; Helacyton gartleri
Family Cell line (CELL)  >>  Uterus cell line (UTRcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_0030 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Monoethanolamine lauryl sulfate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 4360 nM (estimated based on the structural similarity with CHEMBL2420019 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.76
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
          DIG Name: Pigment yellow 3 Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 630 nM (estimated based on the structural similarity with CHEMBL1807120 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.80141844
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
          DIG Name: Benzododecinium bromide Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 3.98 ug.mL-1 (tested by experiment) [3]
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
          DIG Name: Beta-mercaptoalanine Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 50000 nM (tested by experiment) [4]
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
          DIG Name: Delfen Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Emulsifying agent; Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 52700 nM (estimated based on the structural similarity with CHEMBL3792763 ) [5]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
          DIG Name: Diethylene glycol monoethyl ether Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Solubilizing agent; Solvent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL155204 ) [6]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
          DIG Name: Stearalkonium chloride Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative; Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 3.98 ug.mL-1 (estimated based on the structural similarity with CHEMBL2355417 ) [3]
                   Structural Similarity Tanimoto coefficient = 0.974025974
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
          DIG Name: Triethanolamine lauryl sulfate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Complexing agent; Emulsifying agent; Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 20300 nM (estimated based on the structural similarity with CHEMBL572050 ) [7]
                   Structural Similarity Tanimoto coefficient = 0.754716981
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0030
References
1 Total synthesis and biological evaluation of clavaminol-G and its analogs. Eur J Med Chem. 2013 Sep; 67:384-9.
2 Synthesis and biological evaluation of 4-nitro-substituted 1,3-diaryltriazenes as a novel class of potent antitumor agents. Eur J Med Chem. 2011 Jul; 46(7):2971-83.
3 Discovery of novel quaternary ammonium compounds based on quinuclidine-3-ol as new potential antimicrobial candidates. Eur J Med Chem. 2019 Feb 1; 163:626-635.
4 Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors. Bioorg Med Chem Lett. 2007 Jul 15; 17(14):3921-4.
5 Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. Eur J Med Chem. 2016 Jun 10; 115:275-90.
6 Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores. J Med Chem. 2007 Mar 8; 50(5):1007-18.
7 Synthesis and biological activity of dialkylphosphocholines. Bioorg Med Chem Lett. 2009 Nov 15; 19(22):6346-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.