Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET02FRZ)
Name	Serotonin transporter (SERT)
Synonyms	Click to Show/Hide the Synonyms of This DBT Solute carrier family 6 member 4; 5HT transporter; 5HTT; HTT; SERT
Family	Potential-driven transporter (PDT) >> Neurotransmitter:sodium symporter (NSS)
Organism	Homo sapiens (Human)
Gene Name	SLC6A4		Gene ID	6532
UniProt ID	SC6A4_HUMAN	(click to find more protein-related data of this DBT)
TTD ID	T27812	(click to find more therapeutic target data of this DBT)
VARIDT ID	DTD0456	(click to find more drug transporter data of this DBT)
	Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence	METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT PGTFKERIIKSITPETPTEIPCGDIRLNAV
Function	Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization.

Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
DIG Name: Cetylpyridinium chloride		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Antimicrobial preservative; Penetration agent; Solubilizing agent; Surfactant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 = 3 uM (tested by experiment)		[1]
Tested Species	Homo sapiens (Human)
UniProt ID	SC6A4_HUMAN
DIG Name: Benzethonium chloride		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Antimicrobial preservative; Surfactant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 = 2.3 uM (tested by experiment)		[1]
Tested Species	Homo sapiens (Human)
UniProt ID	SC6A4_HUMAN
DIG Name: Methylene blue		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Colorant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 = 8.3 uM (tested by experiment)		[1]
Tested Species	Homo sapiens (Human)
UniProt ID	SC6A4_HUMAN
DIG Name: Phenylmercuric acetate		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Antimicrobial preservative
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 = 5.1 uM (tested by experiment)		[1]
Tested Species	Homo sapiens (Human)
UniProt ID	SC6A4_HUMAN

References
1	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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