Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET04NWK)
Name
Anthrax toxin receptor 2 (CMG-2)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Capillary morphogenesis gene 2 protein; CMG-2
Family Other protein families (OPF)  >>  Anthrax toxin receptor (ATR)
Organism
Homo sapiens (Human)
Gene Name ANTXR2 Gene ID
118429
UniProt ID ANTR2_HUMAN (click to find more protein-related data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWI
EIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYI
HEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLD
FEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLS
GRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGG
KSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAP
KEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPE
ETEEPIRPRPPRPKPTHQPPQTKWYTPIKGRLDALWALLRRQYDRVSLMRPQEGDEVCIW
ECIEKELTA
Function
Necessary for cellular interactions with laminin and the extracellular matrix.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Propyl gallate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative; Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 300000 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID ANTR2_HUMAN
          DIG Name: Tannic acid Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 300000 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID ANTR2_HUMAN
References
1 1,2,3,4,6-Penta-O-galloyl--D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2. J Med Chem. 2013 Mar 14; 56(5):1940-5.

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