Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET04VNT)
Name
Glycogen synthase kinase-3 beta (GSK3B)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Serine/threonine-protein kinase GSK3B; GSK-3 beta
Family Transferase (TFase)  >>  Kinase (EC 2.7)
Organism
Homo sapiens (Human)
Gene Name GSK3B Gene ID
2932
UniProt ID GSK3B_HUMAN (click to find more protein-related data of this DBT)
TTD ID T70977 (click to find more therapeutic target data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Function
Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Neohesperidin dihydrochalcone Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 100000 nM (estimated based on the structural similarity with CHEMBL449317 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.975308642
                   Tested Species Homo sapiens (Human)
                   UniProt ID GSK3B_HUMAN
References
1 Flavonoids as lead compounds modulating the enzyme targets in Alzheimers disease. Med Chem Res (2013) 22:3061-3075.

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