Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET05LKX) | |||||
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| Name |
Lipid transfer protein I (CETP)
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| Synonyms |
Click to Show/Hide the Synonyms of This DBT
Cholesterol ester transfer protein; Lipid transfer protein I
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| Family | Transmembrane channel/porin (TC/P) >> Bactericidal permeability increasing protein (BPIP) | ||||
| Organism |
Homo sapiens (Human)
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| Gene Name | CETP | Gene ID | |||
| UniProt ID | CETP_HUMAN | (click to find more protein-related data of this DBT) | |||
| TTD ID | T15334 | (click to find more therapeutic target data of this DBT) | |||
| Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
| Sequence |
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF PEHLLVDFLQSLS |
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| Function |
Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination. Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles.
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| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Hydroxyethylamine | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Alkalizing agent; Emulsifying agent; Solvent
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 600 nM (estimated based on the structural similarity with CHEMBL3330297 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 0.774193548 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CETP_HUMAN | |||||
| References | |||||
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| 1 | Some molecular targets for antihyperlipidemic drug research. Eur J Med Chem. 2014 Oct 6; 85:535-68. | ||||
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