Details of the Biological Target of DIG (DBT)
General Information of DBT (ID: ET0CL6Y) | |||||
---|---|---|---|---|---|
Name |
Noradrenaline N-methyltransferase (PNMT)
|
||||
Synonyms |
Click to Show/Hide the Synonyms of This DBT
Phenylethanolamine N-methyltransferase; PNMTase; PENT; PNMT
|
||||
Family | Transferase (TFase) >> Methylase (EC 2.1) | ||||
Organism |
Homo sapiens (Human)
|
||||
Gene Name | PNMT | Gene ID | |||
UniProt ID | PNMT_HUMAN | (click to find more protein-related data of this DBT) | |||
TTD ID | T56496 | (click to find more therapeutic target data of this DBT) | |||
INTEDE ID | DME0543 | (click to find more drug-metabolizing enzyme data of this DBT) | |||
Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
Sequence |
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL |
||||
Function |
Converts noradrenaline to adrenaline.
|
||||
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
---|---|---|---|---|---|---|
DIG Name: Monoethanolamine lauryl sulfate | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Surfactant
|
|||||
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 = 109000 nM (estimated based on the structural similarity with CHEMBL18542 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.76 | |||||
Tested Species | Bos taurus (Bovine) | |||||
UniProt ID | PNMT_BOVIN | |||||
DIG Name: Glutaral | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
|
|||||
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 = 345000 nM (estimated based on the structural similarity with CHEMBL18602 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.88 | |||||
Tested Species | Bos taurus (Bovine) | |||||
UniProt ID | PNMT_BOVIN | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.